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A cooperative water effect in proazaphosphatrane-catalysed heterocycle synthesis. | LitMetric

A cooperative water effect in proazaphosphatrane-catalysed heterocycle synthesis.

Chem Commun (Camb)

Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Published: March 2014

The synthesis of oxazolines and imidazolines was achieved by activation of isocyanides with water. Mechanistic studies show that the organosuperbase proazaphosphatrane is tolerant of water within the reaction medium, with a beneficial and cooperative effect being observed.

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Source
http://dx.doi.org/10.1039/c3cc49808eDOI Listing

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