Assessing the photochemical transformation pathways of acetaminophen relevant to surface waters: transformation kinetics, intermediates, and modelling.

Water Res

Università degli Studi di Torino, Dipartimento di Chimica, Via P. Giuria 5, 10125 Torino, Italy; Università degli Studi di Torino, Centro Interdipartimentale NatRisk, Via L. Da Vinci 44, 10095 Grugliasco, TO, Italy. Electronic address:

Published: April 2014

AI Article Synopsis

Article Abstract

This work shows that the main photochemical pathways of acetaminophen (APAP) transformation in surface waters would be direct photolysis (with quantum yield of (4.57 ± 0.17)⋅10(-2)), reaction with CO3(-·) (most significant at pH > 7, with second-order rate constant of (3.8 ± 1.1)⋅10(8) M(-1) s(-1)) and possibly, for dissolved organic carbon higher than 5 mg C L(-1), reaction with the triplet states of chromophoric dissolved organic matter ((3)CDOM*). The modelled photochemical half-life time of APAP in environmental waters would range from days to few weeks in summertime, which suggests that the importance of phototransformation might be comparable to biodegradation. APAP transformation by the main photochemical pathways yields hydroxylated derivatives, ring-opening compounds as well as dimers and trimers (at elevated concentration levels). In the case of (3)CDOM* (for which the triplet state of anthraquinone-2-sulphonate was used as proxy), ring rearrangement is also hypothesised. Photochemistry would produce different transformation products (TPs) of APAP than microbial biodegradation or human metabolism, thus the relevant TPs might be used as markers of APAP photochemical reaction pathways in environmental waters.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.watres.2014.01.016DOI Listing

Publication Analysis

Top Keywords

pathways acetaminophen
8
surface waters
8
main photochemical
8
photochemical pathways
8
apap transformation
8
dissolved organic
8
environmental waters
8
transformation
5
apap
5
assessing photochemical
4

Similar Publications

Multi-Omics and Network-Based Drug Repurposing for Septic Cardiomyopathy.

Pharmaceuticals (Basel)

January 2025

Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin 150081, China.

Background/objectives: Septic cardiomyopathy (SCM) is a severe cardiac complication of sepsis, characterized by cardiac dysfunction with limited effective treatments. This study aimed to identify repurposable drugs for SCM by integrated multi-omics and network analyses.

Methods: We generated a mouse model of SCM induced by lipopolysaccharide (LPS) and then obtained comprehensive metabolic and genetic data from SCM mouse hearts using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and RNA sequencing (RNA-seq).

View Article and Find Full Text PDF

Light-dependent Br-org production in terrestrial plants under acetaminophen stress and the bromination mechanisms mediated by photosystem.

J Environ Sci (China)

July 2025

School of Environmental Science and Engineering, Shandong Key Laboratory of Environmental Processes and Health, Shandong University, Qingdao 266237, China; Laboratory of Marine Ecological Environment in Universities of Shandong, Shandong University, Qingdao 266237, China; Qingdao Key Laboratory of Marine Pollutant Prevention, Shandong University, Qingdao 266237, China; Shandong Kenli Petrochemical Group Co., Ltd., Dongying 257500, China. Electronic address:

Due to the endocrine toxicity, neurotoxic, and reproductive toxicity to organisms, the sources and risks of brominated organic pollutants have attracted widespread attention. However, knowledge gaps remain in the bromination processes of emerging phenolic pollutants in plants, which may increase the potential health risk associated with food exposure. Our study discovered that light induced generation and accumulation of more toxic brominated organic compounds (Br-org) in lettuce leaves under the stress of acetaminophen (ACE) than that without light, as evidenced by an increase in C-Br bond intensity in FTIR analysis.

View Article and Find Full Text PDF

Background: Methylcinnamate (MC), a safe flavoring agent naturally found in Occimum basilicum L. is reported to have an anti-inflammatory responses in various disease models. Acetaminophen (APAP) toxicity is a significant contributor to acute liver injury, which leads to oxidative stress and inflammation.

View Article and Find Full Text PDF

Integrated omics analyses elucidate acetaminophen biodegradation by Enterobacter sp. APAP_BS8.

J Environ Manage

January 2025

Department of Botany, Institute of Science, Banaras Hindu University, Varanasi, 221005, India. Electronic address:

Acetaminophen (APAP) is an extensively consumed over-the-counter and prescribed medication and a constituent of many active pharmaceutical compounds as well as personal care products. Its wide-scale prevalence in the environment due to inefficient treatment technologies has classified APAP as a contaminant of emerging concern. Thus, it is imperative to explore efficient and sustainable methods for remediation of contaminated environments.

View Article and Find Full Text PDF

Acetaminophen (APAP) stands as one of the most prevalent triggers of drug-induced acute liver injury (ALI). The intricate modulation of immune system activation and inflammatory cascades by hepatic immune cells is paramount in managing liver injury and subsequent restoration. In this study, we employed an integrative approach that fused our proprietary flow cytometry analyses across various time points post-APAP injury with publicly available single-cell RNA sequencing (scRNA-seq) datasets, encompassing time-series data from liver tissue of mice subjected to APAP intoxication.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!