Since its discovery close to twenty years ago, the ARF tumor suppressor has played a pivotal role in the field of cancer biology. Elucidating ARF's basal physiological function in the cell has been the focal interest of numerous laboratories throughout the world for many years. Our current understanding of ARF is constantly evolving to include novel frameworks for conceptualizing the regulation of this critical tumor suppressor. As a result of this complexity, there is great need to broaden our understanding of the intricacies governing the biology of the ARF tumor suppressor. The ARF tumor suppressor is a key sensor of signals that instruct a cell to grow and proliferate and is appropriately localized in nucleoli to limit these processes. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease.
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| http://dx.doi.org/10.1016/j.bbadis.2014.01.016 | DOI Listing |
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View Article and Find Full Text PDFArticle Synopsis
- The tumor suppressors p53 and ARF are crucial for controlling cell growth, and their loss is commonly linked to aggressive cancer forms.
- When both p53 and ARF are non-functional, it leads to increased cell proliferation through heightened type I interferon signaling and active STAT1.
- Research indicates that blocking JAK1, a kinase involved in this signaling pathway, can prevent the proliferation of tumors lacking p53 and ARF, presenting a potential treatment strategy for these aggressive cancers.
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