AI Article Synopsis
- A new method is introduced to reduce unwanted side reactions in gold-sensing systems that rely on alkyne activation.
- By increasing steric strain in the area where the reaction occurs, the process involving gold ions is sped up, minimizing side reactions.
- This leads to probes with great sensitivity and selectivity for gold, and it also enables live cell imaging of gold species using a FRET technique.
Article Abstract
A novel approach to suppress the side reactions observed in the reaction-based gold-sensing systems based on the alkyne activation is disclosed. By elevating steric strain around the reaction site, the gold ion promoted ring-opening process in rhodamine-lactam probes is significantly accelerated, which also leads to suppression of those possible side reactions. As a result, the probes show very high sensitivity in addition to excellent selectivity toward gold species. Furthermore, bioimaging of gold species in live cells was demonstrated with a FRET version.
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| http://dx.doi.org/10.1021/ol5001389 | DOI Listing |
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