Seventy percent of the AIDS patients have neurological complications. Seizures are one of the complications and can occur at any stage. Seizures can be life-threatening and treatment with anticonvulsants is warranted. The therapeutic dilemma occurs in this case because of the interactions between the anticonvulsants, especially the first generation anticonvulsants, with antiretroviral agents resulting in significant side-effects including toxicity. The non-availability of second-generation anticonvulsants and cost constraints further limit the choices for the physicians. In this mini-review, we discuss the management of AIDS related seizures with emphasis on the drug-drug interactions between anticonvulsants and antiretroviral agents. We will also address the future directions and the need for prospective studies with second-generation anticonvulsants.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906636 | PMC |
| http://dx.doi.org/10.3389/fneur.2014.00010 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The association between ambient particulate matter exposure and anemia in HIV/AIDS patients.
Epidemiology
December 2024
Department of Global Health, School of Public Health, Wuhan University, 115# Donghu Road, Wuhan, 430071, China.
Background: Anemia is common among HIV/AIDS patients, impacting prognosis. Particulate matter (PM) exposure is an understudied, potentially modifiable risk factor in this group.
Methods: We gathered 36,266 hemoglobin (Hb) measurements from 6,808 HIV/AIDS patients from the HIV/AIDS Comprehensive Response Information Management System from January 1, 2004, to December 31, 2021.
Predictive Factors of ART Follow-Up Loss in HIV Patients (2018-2022): A Retrospective Cohort Study.
AIDS Behav
December 2024
School of Public Health, Southwest Medical University, Luzhou City, 646000, Sichuan Province, China.
Loss to follow-up (LTFU) in antiretroviral therapy (ART) poses significant challenges in the management of HIV/AIDS. This study aims to identify socio-demographic and clinical factors influencing LTFU among patients undergoing ART in Luzhou, China, and to develop a predictive model for LTFU using Cox risk regression analysis. In this retrospective cohort study, data from 8,770 patients diagnosed with HIV infection between January 1, 2018 and December 31, 2022 who were enrolled in the national free ART program were analyzed.
View Article and Find Full Text PDFHarnessing microbes for heavy metal remediation: mechanisms and prospects.
Environ Monit Assess
December 2024
Department of Plant Pathology and Entomology, VIT-School of Agricultural Innovation and Advanced Learning, Vellore Institute of Technology, 632014, Vellore, Tamil Nadu, India.
Contamination by heavy metals (HMs) poses a significant threat to the ecosystem and its associated micro and macroorganisms, leading to ill effects on humans which necessitate the requirement of effective remediation strategies. Microbial remediation leverages the natural metabolic abilities of microbes to overcome heavy metal pollution effectively. Some of the mechanisms that aids in the removal of heavy metals includes bioaccumulation, biosorption, and biomineralization.
View Article and Find Full Text PDFPredictive modeling of cattle calving time emphasizing abnormal and normal cases by using posture analysis.
Sci Rep
December 2024
Graduate School of Engineering, University of Miyazaki, Miyazaki, 889-2192, Japan.
Accurate calving time prediction plays a critical role in ensuring the well-being of both mother and calf during parturition. Challenges during the calving process, particularly in abnormal cases, often necessitate human intervention to prevent potentially fatal outcomes. This study proposes a novel system for automated prediction of normal and abnormal cattle calving cases based on posture analysis.
View Article and Find Full Text PDFAudiology Through a Psychologically Informed Practice Lens.
Ear Hear
November 2024
National Acoustic Laboratories, Sydney, Australia.
Psychologically informed practice is a structural framework originating in physiotherapy, that aids clinicians to identify, consider, and address the psychological factors related to chronic conditions and their management. Hearing loss is a chronic condition associated with a variety of psychosocial impacts, and psychological factors are known to heavily influence the engagement, adherence, and success of hearing rehabilitation. This framework could provide a structured method to manage these factors by using evidence-based psychological theory and applications.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!