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Identification and mechanism analysis of biomarkers related to butyrate metabolism in COVID-19 patients.
Ann Med
December 2025
Department of Assisted Reproductive Centre, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, China.
Background: Butyrate may inhibit SARS-CoV-2 replication and affect the development of COVID-19. However, there have been no systematic comprehensive analyses of the role of butyrate metabolism-related genes (BMRGs) in COVID-19.
Methods: We performed differential expression analysis of BMRGs in the brain, liver and pancreas of COVID-19 patients and controls in GSE157852 and GSE151803.
Clinical characteristics and outcomes of chronic obstructive pulmonary disease patients with family history of chronic airway disease.
Ann Med
December 2025
Department of Pulmonary and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Background: Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous condition with different risk factors, including family history. This study aimed to explore association between a family history of chronic airway disease and features and outcomes of COPD.
Methods: Participants were obtained from the RealDTC study between December 2016 and December 2022.
Ability and utility of the Physician Well-Being Index to identify distress among Chinese physicians.
Ann Med
December 2025
Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Background: Despite the high prevalence of mental stress among physicians, reliable screening tools are scarce. This study aimed to evaluate the capability of the Physician Well-Being Index (PWBI) in identifying distress and adverse consequences among Chinese physicians.
Methods: This cross-sectional online survey recruited 2803 physicians from Southern Mainland China snowball sampling between October and December 2020.
Healthy nudges: exploring their variability, limitations, and future challenges.
Gac Sanit
March 2025
Financial Economics and Accounting Department, University of Alicante, Alicante, Spain.
Objective: To review several behavioral economics-based interventions ("healthy nudges") aimed at mitigating the overuse and underuse of healthcare resources -phenomena associated with poorer health outcomes and increased costs.
Method: A comparative case study approach is used to assess the effectiveness of ten studies designed to improve treatment adherence and prevent underuse, as well as those focused on improving prescribing practices to address overuse.
Results: First, healthy nudges are generally effective, although there is considerable variability in their outcomes.
Global fixed-time position-constrained guidance and adaptive fuzzy prescribed performance control using novel shift function for multiple unmanned surface vehicles formation.
ISA Trans
March 2025
School of Automation, Harbin University of Science and Technology, 150080, Harbin, China. Electronic address:
Guidance and control of multiple unmanned surface vehicles (Multi-USVs) present many challenges due to their under-actuation and the unknown environmental disturbance. This research addresses the formation guidance and control problems of multi-USVs by designing a global fixed-time constrained guidance and control formation approach. First, a global fixed-time control Lyapunov function (GFCLF) is proposed using an innovative shift function to deal with the fixed-time output partial constraint.
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