A new synthetic route to access diarylmethyl phosphonates is presented. The transformation enables the introduction of aromatic groups on benzylic phosphonates via a deprotonative cross-coupling process (DCCP). The Pd(OAc)2/CataCXium A-based catalyst afforded a reaction between benzyl diisopropyl phosphonate derivatives and aryl bromides in good to excellent isolated yields (64-92%).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993846 | PMC |
| http://dx.doi.org/10.1021/ol5002413 | DOI Listing |
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