Background: Standard assessment instruments cannot differentiate patients with minimal residual hand function after stroke. As a result, changes in motor recovery are difficult to document using currently-available tests. In a controlled study with chronic stroke patients without residual finger extension, a new hand function test has been developed. This instrument, called Broetz Hand Test (BzH), allows to assess small variations in hand function in severely paralyzed stoke patients. The instrument is easy to use, and was developed using principles of motor learning and behavioral assessment.
Methods: The instrument consists of seven daily life-oriented tasks, each of which asks for movement of the paralyzed hand. BzH of 20 patients after stroke was evaluated before and after a behavioral physiotherapy treatment. Sensitivity, inter-observer reliability, test-retest reliability and construct validity was calculated.
Results: Two-tailed paired-samples t-test before and after treatment demonstrated sufficient sensitivity. Mean agreement between the raters resulted in an excellent interrater-reliability. Test-retest reliability between the pre- and post-treatment scores was 0.9. The correlation between BzH and standard test scores was statistically significant and demonstrated sufficient validity.
Conclusion: The BzH is a valid and reliable tool to assess changes in hand function in severely paralyzed patients after stroke.
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http://dx.doi.org/10.3233/NRE-141063 | DOI Listing |
J Appl Microbiol
March 2025
Hainan Provincial Key Laboratory for Tropical Hydrobiology and Biotechnology, Hainan University, Haikou 570228 Hainan Province, China.
Aim: This study aimed to investigate the role of two flgJ genes in flagellar assembly and biofilm regulation in Vibrio alginolyticus.
Methods And Results: To investigate the functions of the flgJ, overexpression and gene knockout techniques were employed. Overexpression of flgJ1 enhanced the strain's growth capacity, leading to a rapid bacterial concentration that initiated biofilm formation.
Anal Chim Acta
May 2025
College of Textile Science and Engineering, Jiangnan University, 1800Lihu Road, Wuxi, 214122, China. Electronic address:
Flexible sweat sensors possess the special potential for continuous non-invasive monitoring of human blood glucose. We put forward a flexible microcolumn array sensor, which is designed for health monitoring by means of detecting glucose levels in sweat and capturing physiological signals related to human movement. With the combination of silk fibroin (SF), waterborne polyurethane (PU), and multi-walled carbon nanotubes (MWCNT), this microcolumn film electrode is able to effectively function as a strain sensor benefiting from the superior mechanical performance of PU.
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Institute of Cognitive Neuroscience, Ruhr University Bochum, Bochum, Germany; Research Center One Health Ruhr, Research Alliance Ruhr, Ruhr University Bochum, Bochum, Germany.
This chapter offers an overview of the literature on human handedness and its assessment in clinical neurologic practice and research. There are two major forms of handedness: hand preference, which describes a subjective preference to use one hand over the other for skilled motor activities like writing, and hand skill, which describes objectively measured mother skill. This chapter gives an overview of widely used questionnaires and tests to assess hand preference and hand skill, as well as suggestions on how to determine handedness categories such as left-handed, right-handed, and mixed-handed based on the results of these questionnaires and tests.
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Department of Psychology and Behavioral Sciences & The State Key Lab of Brain-Machine Intelligence, Zhejiang University, Hangzhou, China; Department of Psychiatry of Sir Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address:
Functional lateralization represents a fundamental aspect of brain organization, where certain cognitive functions are specialized in one hemisphere over the other. Deviations from typical patterns of lateralization often manifest in various brain disorders, such as autism spectrum disorder, schizophrenia, and dyslexia. However, despite its importance, uncovering the intrinsic properties of brain lateralization and its underlying structural basis remains challenging.
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Language & Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands; Department of Cognitive Neuroscience & Donders Community for Medical Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:
Left-right asymmetry is an important aspect of human brain organization for functions including language and hand motor control, which can be altered in some psychiatric traits. The last 5 years have seen rapid advances in the identification of specific genes linked to variation in asymmetry of the human brain and/or handedness. These advances have been driven by a new generation of large-scale genome-wide association studies, carried out in samples ranging from roughly 16,000 to over 1.
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