AI Article Synopsis
- The study compared immune cell distribution in healthy dogs versus those with chronic gastrointestinal disease, dental and skin conditions, and cancer.
- Dogs with gastrointestinal and dental/skin issues showed similar immune profiles to healthy dogs, while cancer-affected dogs had significantly lower levels of T cytotoxic cells and MHC class II expressing lymphocytes.
- The findings indicate that immune changes are primarily linked to cancer in dogs, suggesting a need for further research on the clinical implications of these differences.
Article Abstract
In the present study, the peripheral blood lymphocyte subset distribution was compared between healthy dogs and dogs with chronic gastrointestinal disease, dental and skin conditions, and cancer. The immunophenotype of the group with chronic gastrointestinal disease and the group with dental and skin conditions showed no statistically significant differences with other groups of healthy or diseased dogs. When compared with healthy dogs, animals with cancer showed significantly lower absolute values of T cytotoxic cells (CD3+, CD8+) and lymphocytes that express major histocompatibility complex (MHC) class II (MHC-II+) in peripheral blood. The results suggest that peripheral blood immunophenotype is mainly altered in dogs with cancer but not in other diseases. Further studies are required to evaluate the clinical relevance of these findings.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/1040638714522464 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!