Flupirtine, a non-opioid central analgesic of a new chemical class, was compared to pentazocine in multicentre trials enrolling a total of 1174 patients with pain due to various causes. Treatment was given, depending on the indication, for between 3 days and 8 weeks. For both drugs rectal as well as oral medication was used. Flupirtine proved to be at least as efficacious as pentazocine and was better tolerated producing about half as many adverse reactions and about one third of the drop out rate.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Efficacy and safety of diclofenac suppository for postoperative pain relief after diagnostic hystero-laparoscopy and dye test: A double-blind, placebo-controlled, randomized trial.
Eur J Obstet Gynecol Reprod Biol X
September 2024
Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Anambra State, Nigeria.
Article Synopsis
- The study aimed to assess the effectiveness and safety of rectal diclofenac for managing postoperative pain in women undergoing diagnostic hystero-laparoscopy and dye test.
- In a double-blind, placebo-controlled trial with 108 participants, pain levels were measured at various time points, showing diclofenac provided slightly lower pain scores but not significantly better than the placebo.
- Overall, while rectal diclofenac was deemed safe, it did not substantially enhance pain relief or patient satisfaction when compared to placebo treatments following surgery.
Type of opioids injected: does it matter? A multicentric cross-sectional study of people who inject drugs.
Drug Alcohol Rev
January 2015
National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, India.
Introduction And Aims: Injecting pharmaceutical opioids for non-medical purposes is a major concern globally. Though pharmaceutical opioids injection is reported in India, the exact proportion of people who inject drugs (PWID) using pharmaceutical opioids is unknown. The objectives of this study were to describe the various types of drugs that are injected by people in India and to analyse the differences between the commonly injected drugs.
View Article and Find Full Text PDFEfficacy and tolerance of flupirtine and pentazocine in two multicentre trials.
Postgrad Med J
May 1988
Homburg Degussa Pharma Gruppe, Frankfurt, Federal Republic of Germany.
Flupirtine, a non-opioid central analgesic of a new chemical class, was compared to pentazocine in multicentre trials enrolling a total of 1174 patients with pain due to various causes. Treatment was given, depending on the indication, for between 3 days and 8 weeks. For both drugs rectal as well as oral medication was used.
View Article and Find Full Text PDFIn this multicentre, double-blind clinical study, the pain-relieving effects of single doses of pirprofen (200 and 400 mg) and pentazocin (100 mg) were compared with those of a placebo in 210 patients after oral surgery. Pirprofen and pentazocin were significantly more effective than the placebo. At either of the two dosage levels, pirprofen proved more active than pentazocin.
View Article and Find Full Text PDFThe analgesic effects of single oral doses of pirprofen (200 and 400 mg), pentazocin (100 mg) and a placebo were compared in a multicentre, double-blind clinical trial involving 168 hospital patients with malignant diseases. Pentazocin 100 mg was as active as, and pirprofen 200 mg more active than the placebo (p less than 0.05).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!