AI Article Synopsis
- * Researchers reviewed data from 85 AIP patients and performed immunostaining on biopsy samples from 46 patients (14 with AIP and 32 with UC).
- * Results showed that while UC can occur with AIP, it is not solely a sign of IgG4-related disease; however, higher levels of IgG4-positive plasma cells in UC patients were linked to more severe disease activity.
Article Abstract
Background/aims: Ulcerative colitis (UC) is sometimes associated with autoimmune pancreatitis (AIP). Infiltration of immunoglobulin G4 (IgG4)-positive plasma cells is sometimes detected in the colonic mucosa of AIP or UC patients. This study aimed to clarify the relation between UC and IgG4.
Methods: Associations with UC were reviewed in 85 AIP patients. IgG4 immunostaining was performed on biopsy specimens from the colonic mucosa of 14 AIP and 32 UC patients.
Results: UC was confirmed in two cases (type 1 AIP, n=1; suspected type 2 AIP, n=1). Abundant infiltration of IgG4-positive plasma cells in the colonic mucosa was detected in the case of suspected type 2 AIP with UC and two cases of type 1 AIP without colitis. Abundant infiltration of IgG4-positive plasma cells was detected in 10 UC cases (IgG4-present, 31%). Although 72% of IgG4-absent UC patients showed mild disease activity, 70% of IgG4-present patients showed moderate to severe disease activity (p<0.05).
Conclusions: UC is sometimes associated with AIP, but it seems that UC is not a manifestation of IgG4-related disease. Infiltration of IgG4-positive plasma cells is sometimes detectable in the colonic mucosa of UC patients and is associated with disease activity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916684 | PMC |
| http://dx.doi.org/10.5009/gnl.2014.8.1.29 | DOI Listing |
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