Sensors (Basel)
Institute of Biochemistry, Vilnius University, Mokslininku 12, LT-08662 Vilnius, Lithuania.
Published: February 2014
In this paper, an amperometric glucose biosensor is modeled numerically. The model is based on non-stationary reaction-diffusion type equations. The model consists of four layers. An enzyme layer lies directly on a working electrode surface. The enzyme layer is attached to an electrode by a polyvinyl alcohol (PVA) coated terylene membrane. This membrane is modeled as a PVA layer and a terylene layer, which have different diffusivities. The fourth layer of the model is the diffusion layer, which is modeled using the Nernst approach. The system of partial differential equations is solved numerically using the finite difference technique. The operation of the biosensor was analyzed computationally with special emphasis on the biosensor response sensitivity to oxygen when the experiment was carried out in aerobic conditions. Particularly, numerical experiments show that the overall biosensor response sensitivity to oxygen is insignificant. The simulation results qualitatively explain and confirm the experimentally observed biosensor behavior.
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http://dx.doi.org/10.3390/s140202578 | DOI Listing |
Sci Rep
January 2025
Department of Chemistry, Amrita School of Physical Sciences Coimbatore, Amrita Vishwa Vidyapeetham, Coimbatore, 641112, India.
Food Chem
March 2025
Department of Chemistry, Isfahan University, Isfahan, Iran.
The preparation of binary metal chalcogenides with ideal architectures can effectively enhance the electrocatalytic properties of these materials, as promising glucose sensors. Herein, CoMn-S spheres were synthesized using CoMn-glycerate as the precursor, followed by a sulfidation reaction. First, glycerate spheres were prepared by solvothermal treatment of Co and Mn ions in isopropanol solvent mixed with glycerol.
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December 2024
Department of Life Science and Green Chemistry, Faculty of Engineering, Saitama Institute of Technology, 1690, Fusaiji, Fukaya, Saitama 369-0293, Japan. Electronic address:
Highly stretchable, adhesive and conductive triblock hydrogel was synthesized and utilized as a flexible and stable bioelectrocatalytic sensing layer of enzyme-based amperometric glucose biosensor. The hydrogel was prepared through one-pot polymerization of 2-acrylamido-2-methyl-1-propanesulfonic acid, methacrylamide, and hydroxyethyl methacrylate. The physical and chemical properties of the hydrogel were characterized with X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy and electrochemical techniques.
View Article and Find Full Text PDFAnal Chem
November 2024
Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California San Diego, La Jolla, California 92093, United States.
Diabetes management demands precise monitoring of key biomarkers, particularly insulin (I) and glucose (G). Herein, we present a bioelectronic chip device that enables the simultaneous detection of I and G in biofluids within 2 min. This dual biosensor chip integrates aptamer-based insulin sensing with enzymatic glucose detection on a single platform, employing a four-electrode sensor chip.
View Article and Find Full Text PDFSensors (Basel)
October 2024
School of Electrical Engineering, Korea University, Seoul 02841, Republic of Korea.
With improvements in medical environments and the widespread use of smartphones, interest in wearable biosensors for continuous body monitoring is growing. We developed a wearable multiplexed bio-sensing system that non-invasively monitors body fluids and integrates with a smartphone application. The system includes sensors, readout circuits, and a microcontroller unit (MCU) for signal processing and wireless communication.
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