Energy scaling of femtosecond fiber lasers has been constrained by nonlinear impairments and optical fiber damage. Reducing the optical irradiance inside the fiber by increasing mode size lowers these effects. Using an erbium-doped higher-order mode fiber with 6000 µm(2) effective area and output fundamental mode re-conversion, we show a breakthrough in pulse energy from a monolithic fiber chirped pulse amplification system using higher-order mode propagation generating 300 µJ pulses with duration <500 fs (FWHM) and peak power >600 MW at 1.55 µm. The erbium-doped HOM fiber has both a record large effective mode area and excellent mode stability, even when coiled to reasonable diameter. This demonstration proves efficacy of a new path for high energy monolithic fiber-optic femtosecond laser systems.
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http://dx.doi.org/10.1364/OE.21.032411 | DOI Listing |
Trends Biochem Sci
December 2024
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia. Electronic address:
Necroptosis is a mode of programmed cell death executed by the mixed lineage kinase domain-like (MLKL) pseudokinase following its activation by the upstream receptor-interacting protein kinase-3 (RIPK3), subsequent to activation of death, Toll-like, and pathogen receptors. The pathway originates in innate immunity, although interest has surged in therapeutically targeting necroptosis owing to its dysregulation in inflammatory diseases. Here, we explore how protein conformation and higher order assembly of the pathway effectors - Z-DNA-binding protein-1 (ZBP1), RIPK1, RIPK3, and MLKL - can be modulated by post-translational modifications, such as phosphorylation, ubiquitylation, and lipidation, and intermolecular interactions to tune activities and modulate necroptotic signaling flux.
View Article and Find Full Text PDFBMC Neurosci
December 2024
The Clinical Hospital of Chengdu Brain Science Institute, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 610054, P.R. China.
Background: Parkinson's disease (PD) is a progressive neurodegenerative disease associated with functional and structural alterations beyond the nigrostriatal dopamine projection. However, the structural-functional (SC-FC) coupling changes in combination with subcortical regions at the network level are rarely investigated in PD.
Methods: SC-FC coupling networks were systematically constructed using the structural connectivity obtained by diffusion tensor imaging and the functional connectivity obtained by resting-state functional magnetic resonance imaging in 53 PD and 72 age- and sex-matched healthy controls (HCs).
Microsyst Nanoeng
December 2024
ECE Department, University of Alberta, 9211-116 St. NW, Edmonton, T6G 1H9, AB, Canada.
Optomechanical sensors provide a platform for probing acoustic/vibrational properties at the micro-scale. Here, we used cavity optomechanical sensors to interrogate the acoustic environment of adjacent air bubbles in water. We report experimental observations of the volume acoustic modes of these bubbles, including both the fundamental Minnaert breathing mode and a family of higher-order modes extending into the megahertz frequency range.
View Article and Find Full Text PDFSensors (Basel)
December 2024
Key Laboratory of Specialty Fiber Optics and Optical Access Networks, Shanghai University, Shanghai 200444, China.
A highly sensitive sensor, which can detect the temperature and strain simultaneously, is proposed using a hollow-core anti-resonant fiber with composite nested tubes. The sensing fiber contains two kinds of nested tubes, and two different sensing mechanisms, the resonance coupling effect and the intermodal interference, are realized in the same section of a hollow-core anti-resonant fiber fully filled with ethanol. Five conjoined nested anti-resonant tubes are introduced to suppress the confinement loss of the higher-order mode LP.
View Article and Find Full Text PDFPhys Rev Lett
November 2024
School of Physics and Electronic Science, East China Normal University, Shanghai 200062, China.
Capturing the intricate dynamics of partially coherent patterns in coupled oscillator systems is vibrant and one of the crucial areas of nonlinear sciences. Considering higher-order Fourier modes in the coupling, we discover a novel type of clustered coherent state in phase models, where inside the coherent region oscillators are further split into q dynamically equivalent subgroups with a 2π/q phase difference between two neighboring subgroups, forming a multicoherent-phase (MUP) chimera state. Both a self-consistency analysis and the Ott-Antonsen dimension reduction techniques are used to theoretically derive these solutions, whose stability are further demonstrated by spectral analysis.
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