We report on a dual output all-PM fiber laser system running at 100 MHz repetition rate offering coherent broadband and narrowband pulses centered at 2.05 µm with a spectral FWHM bandwidth of 60 nm and 1.5 nm at up to 360 mW and 500 mW, respectively. The broadband pulses are compressed down to 135 fs. The multi-stage double-clad amplifier based on Tm/Ho codoping is seeded by a supercontinuum light source, spanning from around 1 µm up to 2.4 µm.
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http://dx.doi.org/10.1364/OE.21.031390 | DOI Listing |
Circ Cardiovasc Interv
December 2024
Canadian VIGOUR Centre (K.R.B., R.C.W., Y.Z., T.T., E.L., C.M.W., P.W.A.), University of Alberta, Edmonton, Canada.
Background: In STREAM-1 (Strategic Reperfusion Early After Myocardial Infarction), excess intracranial hemorrhage occurred in patients aged ≥75 years receiving full-dose tenecteplase as part of a pharmaco-invasive strategy, whereas no further intracranial hemorrhage occurred after halving the tenecteplase dose. In STREAM-2 (Second Strategic Reperfusion Early After Myocardial Infarction), half-dose tenecteplase was an effective and safe pharmaco-invasive strategy in older patients with ST-segment-elevation myocardial infarction presenting within <3 hours, compared with primary percutaneous coronary intervention (PCI). We prespecified evaluating the efficacy and safety of a half-dose versus full-dose pharmaco-invasive strategy and compared the half-dose pharmaco-invasive strategy to primary PCI in patients aged ≥75 years.
View Article and Find Full Text PDFCirculation
January 2022
Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas (S.R., A.P.).
Background: Socioeconomic disadvantage is a strong determinant of adverse outcomes in patients with heart failure. However, the contribution of community-level economic distress to adverse outcomes in heart failure may differ across races and ethnicities.
Methods: Patients of self-reported Black, White, and Hispanic race and ethnicity hospitalized with heart failure between 2014 and 2019 were identified from the Medicare MedPAR Part A 100% Files.
Neurology
August 2021
From the NIHR University College London Hospitals Biomedical Research Centre (M.M.W., J.W.S.), UCL Queen Square Institute of Neurology; Chalfont Centre for Epilepsy (M.M.W., J.W.S.), Chalfont St. Peter, UK; Neurology Unit (M.M.W., J.M., Y.W.N.), Department of Medicine, University of Maiduguri Teaching Hospital. PMB 1414, Borno State; Neurology Unit (S.A.B.), Department of Medicine, Usman Danfodiyo University Teaching Hospital, Sokoto, Sokoto State; Department of Medicine (M.A.K., M.B.F.), Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Osun State; Department of Psychiatry (S.C.I.), Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi State, Nigeria; Biomedical MR Imaging and Spectroscopy Group (W.M.O.), Center for Image Sciences, University Medical Center Utrecht and Utrecht University; Department of Pediatric Neurology (W.M.O., E.v.D.), UMC Utrecht Brain Center, University Medical Center Utrecht, the Netherlands; Department of Clinical and Movement Neurosciences (O.O.), UCL Queen Square Institute of Neurology, London, UK; Department of Mental Health (A.A.M.), Federal Neuropsychiatric Hospital Maiduguri, Borno State; Federal Medical Center (I.A.) Azare, Bauchi State; Department of Clinical Pharmacy and Pharmacy Practice (E.W.H.), Faculty of Pharmaceutical Sciences, Gombe State University; Department of Neurology (G.S.) and Research and Development Unit (G.S.), Dayanand Medical College, Ludhiana, India; Centre for Global Health (A.W.S.), Institute of Health and Society, University of Oslo, Norway; Center for Global Health (A.W.S.), Department of Neurology, Technical University Munich, Germany; and Stichting Epilepsie Instellingen Nederland (J.W.S.), Achterweg 5, SW Heemstede, the Netherlands.
Background: We determined the prevalence, incidence, and risk factors for epilepsy in Nigeria.
Methods: We conducted a door-to-door survey to identify cases of epilepsy in 3 regions. We estimated age-standardized prevalence adjusted for nonresponse and sensitivity and the 1-year retrospective incidence for active epilepsy.
Urology
October 2020
Department of Pediatric Surgery and Urology, School of Medicine in Katowice, Medical University of Silesia in Katowice, Katowice, Poland.
Aggressive angiomyxoma (AAM) is a rare tumor with a high risk of local recurrence. Scrotal AAM mimics common pediatric pathologies including hernia or hydrocele. We present 11-year-old boy who underwent macroscopically radical excision of right scrotal AAM.
View Article and Find Full Text PDFCells
December 2019
Regenerative Medicine & Fibrosis Group, Institute for Liver and Digestive Health, University College London (UCL), London NW3 2PF, UK.
An altered liver microenvironment characterized by a dysregulated extracellular matrix (ECM) supports the development and progression of hepatocellular carcinoma (HCC). The development of experimental platforms able to reproduce these physio-pathological conditions is essential in order to identify and validate new therapeutic targets for HCC. The aim of this work was to validate a new in vitro model based on engineering three-dimensional (3D) healthy and cirrhotic human liver scaffolds with HCC cells recreating the micro-environmental features favoring HCC.
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