Moxifloxacin-resistant Mycobacterium tuberculosis mutants were selected in vitro using different concentrations of moxifloxacin. gyrA mutations at codons 88 and 94 were associated with resistance (defined as an MIC of ≥2 μg/ml) (P < 0.0001 and P = 0.0053, respectively). Despite the presence of gyrA mutations, moxifloxacin significantly impedes bacterial growth, supporting its use for the treatment of ofloxacin-resistant M. tuberculosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993264 | PMC |
| http://dx.doi.org/10.1128/AAC.02583-13 | DOI Listing |
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