Objectives: Excessive daytime sleepiness (EDS) is associated with significant personal and medical burden. However, there is little indication of the impact of these symptoms in the broader population.
Participants And Methods: We studied 946 men ages 24-92 years (median age, 59.4 [interquartile range {IQR}, 45-73 years]) and 1104 women ages 20-94 years (median age, 50 [IQR, 34-65 years]) who resided in the Barwon Statistical Division, South-Eastern Australia, and participated in the Geelong Osteoporosis Study (GOS) between the years of 2001 and 2008. EDS was defined as an Epworth Sleepiness Scale (ESS) score of ⩾ 10. Lifestyle factors, history of medical conditions, and medication history were documented by self-report.
Results: For men, the age-specific prevalence of EDS was 5.1% (ages 20-29 years), 6.4% (ages 30-39 years), 9.8% (ages 40-49 years), 15.5% (ages 50-59 years), 12.0% (ages 60-69 years), 12.0% (ages 70-79 years), and 29.0% (ages ⩾ 80 years). For women, the age-specific prevalence of EDS was 14.7% (ages 20-29 years), 8.7% (ages 30-39 years), 15.0% (ages 40-49 years), 16.0% (ages 50-59 years), 12.6% (ages 60-69 years), 13.2% (ages 70-79 years), and 17.0% (ages ⩾ 80 years). Overall standardized prevalence of EDS was 10.4% (95% confidence interval, 9.7-11.2) for men and 13.6% (95% confidence interval, 12.8-14.4) for women.
Conclusions: The prevalence of EDS increased with age, affecting approximately one-third of those aged ⩾ 80 years. Because EDS has been associated with poorer health outcomes in the older age strata, these findings suggest that routine screening may be beneficial in ongoing health assessments for these individuals. Overall, more than one-tenth of the Australian adult population has EDS, which is indicative of possible underlying sleep pathology.
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http://dx.doi.org/10.1016/j.sleep.2013.11.783 | DOI Listing |
Arthritis Res Ther
January 2025
Department of Medical Science and Public Health, Rheumatology Unit, University of Cagliari, Azienda Ospedaliero Universitaria di Cagliari, SS 554 Monserrato (CA), Bivio Sestu, Monserrato, 09042, Italy.
Objectives: To explore the role of newly emerging autoantibodies (AAbs) - peptidyl-arginine deiminase 4 (aPAD4), carbamylated proteins (aCarP), and anti-RA33 (aRA33) - alongside the traditionally assessed rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA), in predicting the response to abatacept (ABT) and its retention rate in rheumatoid arthritis (RA) patients.
Methods: Data from 121 consecutive ABT-treated RA patients were recorded. The RF and ACPA status were retrospectively assessed by reviewing the patients' clinical records.
Eur J Med Res
January 2025
China Medical University, Shenyang, Liaoning, China.
Background: Infrared thermography technology is a diagnostic imaging modality that converts temperature information on the surface of the human body into visualised thermograms. This technology has the capacity to intuitively detect the presence of certain abnormal conditions or foci in the human body. In recent years, the application of this technology in medicine has become increasingly extensive, especially in the areas of auxiliary diagnosis and early screening of diseases.
View Article and Find Full Text PDFNeurol Res Pract
January 2025
Department of Vascular Neurology, University Hospital Bonn, Bonn, Germany.
Background: Nitrous oxide (N₂O), commonly known as laughing gas, is widely recognized for its anesthetic and analgesic effects, and is frequently used in medical contexts. However, its misuse can lead to significant neurological complications, which are often under-recognized in clinical practice. Recent data on such cases in Germany are rare.
View Article and Find Full Text PDFTrop Med Health
January 2025
Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Background: Neurobrucellosis, a serious central nervous system infection caused by Brucella species, presents significant challenges due to its diverse clinical manifestations and the risk of long-term complications and poor outcomes. Identifying predictors of adverse outcomes is critical for improving patient management and overall prognosis.
Objectives: This study aimed to evaluate the long-term morbidity and mortality associated with neurobrucellosis and to identify key predictors of adverse outcomes.
J Neuroimaging
January 2025
Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Background And Purpose: MRI is crucial for multiple sclerosis (MS), but the relative value of portable ultra-low field MRI (pULF-MRI), a technology that holds promise for extending access to MRI, is unknown. We assessed white matter lesion (WML) detection on pULF-MRI compared to high-field MRI (HF-MRI), focusing on blinded assessments, assessor self-training, and multiplanar acquisitions.
Methods: Fifty-five adults with MS underwent pULF-MRI following their HF-MRI.
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