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Elevated neurofilament light chain associated with cobalt/chromium metal neurotoxicity in a patient with a failed hip implant.
Clin Chim Acta
December 2024
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA. Electronic address:
Background: It is known that the heavy metals cobalt and chromium are associated with neurotoxicity. Chromium (Cr) and Cobalt (Co) are both components of metal-on-metal (MoM) implants which can be degraded/fragmented and released into the bloodstream. Neurofilament Light Chain (NfL) is a neuron-specific protein that increases in serum following axonal damage.
View Article and Find Full Text PDFAdverse Local Tissue Reaction and Osteolysis After Ceramic-on-Ceramic Total Hip Arthroplasty.
Arthroplast Today
December 2024
Department of Orthopaedic Surgery, Changi General Hospital, Singapore.
Adverse local tissue reaction (ALTR) and osteolysis formation are more frequently described complications after total hip arthroplasty (THA) with metal-on-metal bearings. In this report, we present a unique case of ALTR and osteolysis formation with ceramic-on-ceramic bearing THA, which has been less commonly described in the existing literature. This rare case occurred in a 54-year-old patient who had a primary THA done 17 years prior to representing to our institution.
View Article and Find Full Text PDFDiagnostic Dilemma: Unusual Post-replacement Hip Pain Following Trauma Leading to Metallosis - A Case Report.
J Orthop Case Rep
December 2024
Department of Orthopaedics, AIIMS Raebareli, Raebareli, Uttar Pradesh, India.
Introduction: Metallosis, characterized by the collection of metallic debris in periarticular tissues, is primarily associated with metal-on-metal bearings in hip arthroplasty. This report presents a rare case of metallosis after metal-on-polyethylene (MoP) total hip arthroplasty (THA), highlighting diagnostic challenges and management strategies. Metallosis following MoP arthroplasty is extremely rare, with only a limited number of documented cases in the literature.
View Article and Find Full Text PDFA comparison of postoperative microbiological and histological test results with the indication for revision as listed at the time of surgery in the National Joint Registry: a single-centre cohort study of metal-on-metal total hip replacement and hip resurfacing revision procedures.
Hip Int
December 2024
Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, Southmead Hospital, Bristol, UK.
Introduction: Surgeons allocate an indication(s) for revision surgery on NJR Minimum Data Set forms in the immediate perioperative period, when results from intraoperative histology and microbiology samples are not available. We evaluated to what extent the postoperative diagnostics obtained for patients undergoing metal-on-metal hip arthroplasty (MoMHA) revision surgery align with the indication for revision listed in the NJR.
Methods: NJR data for MoMHA revision patients (2004-2015) at a single centre were linked to hospital records of microbiology and histology testing for prosthetic joint infection (PJI) and adverse reaction to metal debris (ARMD).
Pseudotumor in Ceramic-on-Ceramic Total Hip Arthroplasty: A Case Report.
Cureus
October 2024
Trauma and Orthopedics, Royal Orthopaedic Hospital, Birmingham, GBR.
Pseudotumors are a rare complication of total hip arthroplasty (THA), arising from local soft tissue reactions. These reactions can lead to painful joint effusions and prosthetic loosening, often necessitating revision surgery. Metal-on-metal and metal-on-polyethylene prostheses are particularly prone to this complication due to the accumulation of metal debris from prosthetic wear, which represents a significant drawback.
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