Snake venom is composed of a mixture of substances that caused in victims a variety of pathophysiological effects. Besides antivenom, literature has described plants able to inhibit injuries and lethal activities induced by snake venoms. This work describes the inhibitory potential of ethanol, hexane, ethyl acetate, or dichloromethane extracts and fractions from stem and leaves of Manilkara subsericea against in vivo (hemorrhagic and edema) and in vitro (clotting, hemolysis, and proteolysis) activities caused by Lachesis muta venom. All the tested activities were totally or at least partially reduced by M. subsericea. However, when L. muta venom was injected into mice 15 min first or after the materials, hemorrhage and edema were not inhibited. Thus, M. subsericea could be used as antivenom in snakebites of L. muta. And, this work also highlights Brazilian flora as a rich source of molecules with antivenom properties.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3910483 | PMC |
| http://dx.doi.org/10.1155/2014/408068 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Data on leaf structural, physiological and nutritional characteristics of species co-occurring in restinga and semidecidual seasonal forest ecosystems.
Data Brief
June 2020
Universidade Estadual do Norte Fluminense Darcy Ribeiro, Laboratório de Biologia Celular e Tecidual, Centro de Biociências e Biotecnologia. Brazil.
This paper presents additional data on the leaf structural, physiological and nutritional characteristics of three species ( e ), co-occurring in restinga and semideciduous seasonal forest (forest). The data of the leaf structural, physiological and nutritional characteristics were obtained from the three species to identify possible adaptive strategies that could explain the co-occurrence of these species in the restinga and forest. In addition, this data can help identify key functional traits in the plant community of restinga and forests that can be employed in the reestablishment of ecological and edaphic processes in these ecosystems.
View Article and Find Full Text PDFExploring the Insecticide and Acaricide Potential of Development Regulators obtained from Restinga vegetation from Brazil.
An Acad Bras Cienc
May 2019
Laboratório de Estudos de Pragas e Parasitas, Departamento de Biologia Celular e Molecular, Universidade Federal Fluminense, Outeiro de São João Batista, s/n Centro, 24020 140 Niterói, RJ, Brazil.
As a part of our continuing search for insect and arthropod development regulators from Brazilian restinga vegetation of the Rio de Janeiro State, crude extracts, purified fractions and essential oils were submitted to screening tests seeking for biological activities on the development of the insects Rhodnius prolixus, Dysdercus peruvianus, Oncopeltus fasciatus and Rhipicephalus (Boophilus) microplus. Up to now, 102 secondary metabolites have been detected in the fractions, among them monoterpenes, sesquiterpenes and two triterpenes which were obtained from the species, Eugenia sulcata, Pilocarpus spicatus, Manilkara subsericea, Myrciaria floribunda and Zanthoxylum caribaeum. These secondary plant metabolites are considered of interest for the use of studies related to arthropod endocrinology, vector-parasite interaction system, and population control of vector insect and agricultural pest.
View Article and Find Full Text PDFMolluscicidal activity of Manilkara subsericea (Mart.) dubard on Biomphalaria glabrata (Say, 1818).
Acta Trop
February 2018
Laboratório de Avaliação e Promoção da Saúde Ambiental. Fiocruz. Brasil Avenue, 4365, Rio de Janeiro, Brazil. Electronic address:
Schistosomiasis is promoted for species from Schistosoma genus affecting over 200 million people worldwide. Molluscicides are an efficient method to control this disease, being able to reduce intermediate host snail Biomphalaria glabrata number. In function of resistance cases using niclosamide, natural products are promisors to discover new drugs.
View Article and Find Full Text PDFSecondary Metabolites from Leaves of Manilkara subsericea (Mart.) Dubard.
Pharmacogn Mag
October 2015
Programa de Pós, Graduação em Biotecnologia Vegetal, Centro de Ciências da Saúde, Bloco K, 2° Andar, Sala 032, Universidade Federal do Rio de Janeiro, UFRJ, Av. Brigadeiro Trompowski s/n, CEP: 21941-590, Ilha do Fundão, RJ, Brazil; Laboratório de Tecnologia de Produtos Naturais, LTPN, Departamento e Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal Fluminense, UFF Rua: Mario Viana, 523, CEP: 24241-000, Santa Rosa, Niterói, RJ, Brazil.
Background: Manilkara subsericea (Sapotaceae) is a species widely spread in the sandbanks of Restinga de Jurubatiba National Park (Rio de Janeiro, Brazil). It is commonly known as "maçaranduba", "maçarandubinha" and "guracica", being used in this locality as food, and timber. However, M.
View Article and Find Full Text PDFDevelopment of an insecticidal nanoemulsion with Manilkara subsericea (Sapotaceae) extract.
J Nanobiotechnology
May 2014
Programa de Pós, Graduação em Biotecnologia Vegetal, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro - UFRJ, Bloco K, 2° andar - sala 032, Av, Brigadeiro Trompowski s/n, CEP: 21941-590 Ilha do Fundão, RJ, Brazil.
Background: Plants have been recognized as a good source of insecticidal agents, since they are able to produce their own defensives to insect attack. Moreover, there is a growing concern worldwide to develop pesticides with low impact to environment and non-target organisms. Hexane-soluble fraction from ethanolic crude extract from fruits of Manilkara subsericea and its triterpenes were considered active against a cotton pest (Dysdercus peruvianus).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!