Objective: To analyze the sequence of a novel human leukocyte antigen (HLA)-A*33:44 allele.
Methods: A novel HLA-A allele was found by double-stranded sequencing combined with single-stranded sequencing. The frequency of the novel allele was determined by population survey.
Results: Genomic sequence of this novel HLA-A*33:44 allele (accession No. HQ873871) has differed from HLA-B*33:03:01 by one nucleotide in exon 4, which resulted in nt 866 G→ A substitution, which results in an amino acid substitution from Gly(GGT) to Asp(GAT) at codon 265. This alternation is a new single nucleotide polymorphism compared with other HLA-A alleles. The frequency of this new allele is less than 0.0003 in Chinese Han population.
Conclusion: A mutation has been found in exon 4 of the novel HLA-A*33:44 allele, which may provide more information for HLA gene study.
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| http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2014.01.020 | DOI Listing |
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