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Differences in mean age at diagnosis of invasive melanoma for men and women, by anatomic site, thickness, and subtype.
Br J Dermatol
December 2024
Department of Population Health, QIMR Berghofer Medical Research Institute, Queensland, Australia.
Background: Understanding the factors influencing age at melanoma diagnosis by sex and anatomic site is crucial for developing effective prevention and early detection strategies. While previous research has highlighted sex-based differences in melanoma incidence by age and anatomic distribution, the underlying mechanisms remain unclear. We aimed to investigate sex-specific patterns in melanoma age at diagnosis across different anatomic sites and thickness categories, considering the potential influence of disease progression and detection rates.
View Article and Find Full Text PDFImpact of Patient's Age and Physician's Professional Background on the Number Needed to Treat in Malignant Melanoma Detection.
Cancers (Basel)
November 2024
Department of Dermatology, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, 93053 Regensburg, Germany.
With regard to excision of pigmented lesions for detection of malignant melanoma (MM), the number needed to treat (NNT) describes the number of melanocytic nevi that need to be biopsied/excised to detect one MM. The aim should be a low NNT. : Single-center data analysis, including dermatohistopathological records of all nevi and MM cases during 2004-2013 at the Department of Dermatology, University Hospital Regensburg (UKR), was performed.
View Article and Find Full Text PDFJAK inhibitors in immune regulation and treatment of vitiligo.
Cytokine Growth Factor Rev
December 2024
Department of Dermatology, Shengjing Hospital of China Medical University, Shenyang, China; Department of Dermatology, The First Hospital of China Medical University, Shenyang, China. Electronic address:
Article Synopsis
- - Vitiligo is a skin disorder characterized by loss of pigmentation, affecting both the appearance and mental well-being of those affected, as it involves a decrease in functioning melanocytes which produce skin color.
- - Treatment options for vitiligo include glucocorticoids, immunosuppressants, phototherapy, and surgical methods, but recent studies highlight the role of Janus kinase (JAK) hyperactivation and pro-inflammatory cytokines in escalating the condition by harming melanocytes.
- - New research shows that JAK inhibitors can effectively counteract the negative effects of these signaling pathways, leading to potential repigmentation of the skin, and this review discusses their mechanisms and applications for improving vitiligo treatments.
Spontaneous ependymoma in a free-ranging juvenile black-horned capuchin (Sapajus nigritus).
J Comp Pathol
November 2024
Veterinary Pathology Laboratory, Department of Veterinary Sciences, Federal University of Paraná, Palotina, Paraná, Brazil.
A young free-ranging black-horned capuchin (Sapajus nigritus) with a history of ataxia, anisocoria, diminished threat and pupil reflexes and increased cranial circumference was referred for evaluation to the Medicine and Wildlife Conservation Section, Federal University of Paraná, Paraná, Brazil. Due to the clinical presentation and radiographic findings of hydrocephalus, euthanasia was performed. Necropsy revealed a dark red mass (1.
View Article and Find Full Text PDF[Effects of the COVID-19 pandemic on inpatient dermatosurgery in Germany : Retrospective evaluation of the surgical cases from nine dermatology clinics].
Dermatologie (Heidelb)
November 2024
Hautklinik, Klinikum Ludwigshafen am Rhein, Ludwigshafen, Deutschland.
Article Synopsis
- The study analyzes the effect of the COVID-19 pandemic on inpatient dermatosurgical care across nine German clinics over three years (2019-2021).
- A total reduction in dermatosurgical cases was observed, with a 14.5% drop in 2020 and an 8.5% drop in 2021 compared to 2019, particularly affecting surgeries for melanoma and benign lesions.
- The findings highlight that while there was a significant decline in 2020, the number of inpatient cases began to stabilize in 2021, indicating ongoing demand for inpatient treatment despite challenges from the pandemic.
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