AI Article Synopsis
- Cadherin 17 is a calcium-dependent protein that helps cells stick together, playing a key role in embryo development and tissue structure.
- It is mainly found in the epithelial cells of the small intestine, colon, and pancreatic ducts in both embryos and adults.
- Cadherin 17 is often present in adenocarcinomas of the gastrointestinal tract and pancreas, making it a valuable marker for differentiating these tumors from other cancers.
Article Abstract
Cadherin 17 is a member of a multigene family of calcium-dependent, transmembrane proteins that mediates cell-cell adhesion, plays important roles during embryogenesis, and is crucial for tissue morphogenesis and maintenance. Cadherin 17 is exclusively expressed in the epithelial cells of embryonic and adult small intestine and colon, and pancreatic ducts. It has also been reported to be frequently expressed in adenocarcinomas arising in the gastrointestinal tract and pancreas. Owing to its restricted expression in these groups of tumors, cadherin 17 has proven to be a useful immunohistochemical marker for assisting in distinguishing these neoplasms from other malignancies with which they may be confused.
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| http://dx.doi.org/10.1097/PAP.0000000000000008 | DOI Listing |
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