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Matrix-mediated activation of murine fibroblast-like synoviocytes.
Exp Cell Res
January 2025
Translational Matrix Biology, University of Cologne, Medical Faculty, Cologne, Germany. Electronic address:
Fibroblast-like synoviocytes (FLS) are key cells promoting cartilage damage and bone loss in rheumatoid arthritis (RA). They are activated to assume an invasive and migratory phenotype. While mechanisms of FLS activation are unknown, evidence suggests that pre-damaged extracellular matrix (ECM) of the cartilage can trigger FLS activation.
View Article and Find Full Text PDFIntegrating network pharmacology to investigate the mechanism of quercetin's action through AKT inhibition in co-expressed genes associated with polycystic ovary syndrome and endometrial cancer.
Int J Biol Macromol
January 2025
Department of Obstetrics and Gynecology, Chongqing General Hospital, Chongqing University, Chongqing 401147, China. Electronic address:
Endometrial cancer (EC) is a common gynecological malignancy for which polycystic ovarian syndrome (PCOS) has been identified as a significant risk factor. Quercetin, a widely distributed natural flavonoid, has demonstrated potential therapeutic effects in managing both PCOS and EC. However, the specific molecular targets of quercetin in the context of PCOS comorbid with EC (PCOS-EC) remain poorly defined.
View Article and Find Full Text PDFTo image or not to image: Use of imaging mass spectrometry in biomedical lipidomics.
Prog Lipid Res
January 2025
Lipids in Human Pathology, Institut d'Investigació Sanitària Illes Balears (IdISBa) - Health Research Institute of the Balearic Islands, Ctra. Valldemossa 79, Module G, Floor -1, E-07120 Palma, Balearic Islands, Spain; Research Unit, University Hospital Son Espases, Ctra Valldemossa 79, E-07120 Palma, Balearic Islands, Spain. Electronic address:
Lipid imaging mass spectrometry (LIMS) allows for establishing the bidimensional distribution of lipid species within a tissue section. One of the main advantages is the generation of spatial information on lipid species distribution at a spatial (lateral) resolution bordering on single-cell resolution with no need to isolate cells. Thus, LIMS images demonstrate, with a level of detail never described before, that lipid profiles are highly sensitive to cell type and pathophysiological state.
View Article and Find Full Text PDFEvolution and ecology of anti-defence systems in phages and plasmids.
Curr Biol
January 2025
Laboratory of Biochemistry, Wageningen University, 6708 WE Wageningen, The Netherlands. Electronic address:
Prokaryotes (Bacteria and Archaea) encode a highly diversified arsenal of defence systems that protect them against mobile genetic elements, such as phages and plasmids. In turn, mobile genetic elements encode anti-defence systems that allow them to escape the activity of these defence systems. This has resulted in an evolutionary arms race in which defence systems and anti-defence systems evolve and adapt continuously, driving intriguing innovation and enormous diversification on both sides.
View Article and Find Full Text PDFNeurotrophin-3 as a mediator in the link between PM exposure and psychiatric disorders: A Mendelian randomization study.
Ecotoxicol Environ Saf
January 2025
School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China; Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan, China; Clinical Research Center of Shandong University, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China. Electronic address:
Background: The causal relationship between PM (particulate matter with an aerodynamic diameter ≤2.5 μm) and common mental disorders, along with its neuropathological mechanisms, remains unclear.
Methods: We used genome-wide association study datasets from the UK Biobank and Psychiatric Genomics Consortium to systematically investigate the causal relationship between PM and nine common psychiatric disorders using two-sample Mendelian randomization (TSMR) methods.
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