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Solitary fibrous tumor occurring at unusual sites: A clinico-pathological series of 31 cases with emphasis on its wide morphological spectrum.
Pathol Res Pract
March 2024
Department of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia", Anatomic Pathology, University of Catania, 95123 Catania, Italy. Electronic address:
Article Synopsis
- - Solitary fibrous tumor (SFT) is a rare tumor that can occur in various locations in adults, with no gender preference, and can present a wide range of morphological appearances.
- - The study examined 31 cases of SFT from diverse sites, including uncommon areas like the thoracic spine, mesorectal tissue, and breast, highlighting the tumor's versatility in location.
- - Notable morphological characteristics observed in the tumors included lipomatous areas, myxoid changes, and features resembling other tumors, which can lead to diagnostic confusion; thus, pathologists need to be vigilant to distinguish SFTs from other neoplasms.
Myxofibrosarcoma involving brachial plexus diagnoses by contrast-enhanced ultrasound: A case report.
Medicine (Baltimore)
December 2023
Department of Ultrasound, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Article Synopsis
- Myxofibrosarcoma is a rare, low-grade cancer that typically presents as a painless mass, but an unusual case involving severe pain and complex growth patterns in the axillary region is reported.
- An 87-year-old male patient had a tumor around the axillary neurovascular bundle, which was difficult to diagnose due to claustrophobia preventing an MRI; ultrasound imaging helped determine the tumor's invasiveness and surrounding metastatic foci.
- The patient underwent an excisional biopsy to minimize risks associated with needle biopsies, leading to a surgical outcome and further histopathological evaluation.
Biology and Management of High-Grade Myxofibrosarcoma: State of the Art and Future Perspectives.
Diagnostics (Basel)
September 2023
Department of Orthopaedic Surgery, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
Myxofibrosarcoma (MFS) is one of the most common adult soft tissue sarcomas, typically arising in the extremities. Histologically, MFS is classified into three grades: low, intermediate, and high. Histological grades correlate with distant metastases and tumor-associated mortality.
View Article and Find Full Text PDFMyxofibrosarcoma in adolescents and young adults: a clinicopathologic study of 17 cases.
Hum Pathol
December 2023
Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA. Electronic address:
Myxofibrosarcoma is a locally aggressive sarcoma that characteristically arises in the extremities of older patients. Cases arising at a younger age are rare, leading to diagnostic challenges. Our aim was to study the clinicopathologic features of myxofibrosarcoma in patients aged ≤40 years.
View Article and Find Full Text PDFMediastinal Myxofibrosarcoma Harboring Loss-of-Function Variant in a Patient With Lynch Syndrome: A Case Report and Literature Review.
Int J Surg Pathol
December 2023
Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA.
Myxofibrosarcoma is a malignant fibroblastic neoplasm that commonly arises in the extremities, with mediastinum being a very rare location. The development of sarcomas is uncommon in patients with Lynch syndrome. We present a Lynch syndrome patient with synchronous cecal adenocarcinoma and mediastinal myxofibrosarcoma with both harboring the same loss-of-function alteration (c.
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