AI Article Synopsis
- - A study aimed to find a biomarker for multiple sclerosis (MS) that indicates potential relapse and disability, focusing on SWAP-70 antibodies in patients with relapsing-remitting MS (RRMS).
- - Researchers tested serum samples from 26 RRMS patients, finding high levels of SWAP-70 antibodies during attacks compared to remission, and noted a significant link between these antibody levels and various disability indicators.
- - The findings suggest that SWAP-70 antibodies could serve as useful biomarkers for MS prediction, but more research is needed to understand their role in disease processes.
Article Abstract
Objective: This study was conducted to identify a biomarker for multiple sclerosis (MS) that can be used as a predictor of relapse and disability.
Materials And Methods: Sera of 26 consecutive relapsing-remitting MS (RRMS) patients were screened for switch-associated protein 70 (SWAP-70) antibody, which was previously identified by protein macroarray. The serum levels of several cytokines, chemokines and soluble adhesion molecules related to MS attacks were measured by enzyme-linked immunosorbent assay (ELISA). A possible correlation was sought among levels of SWAP-70 antibody, measured humoral factors and disability scores.
Results: ELISA studies showed high-titre SWAP-70 antibodies in 16 (61.5%) RRMS sera obtained during the attack period and 9 (34.6%) sera obtained during remission. There was a significant inverse correlation between SWAP-70 antibody levels and expanded disability status scale scores, CXCL10, soluble VCAM-1, CXCL13 and soluble VLA-4 levels.
Conclusion: Our results showed that SWAP-70 antibodies could potentially be utilized as relapse and prognostic biomarkers in MS. Whether or not SWAP-70 antibodies have any effect on disease mechanisms requires further investigation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586872 | PMC |
| http://dx.doi.org/10.1159/000358221 | DOI Listing |
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Article Synopsis
- - A study aimed to find a biomarker for multiple sclerosis (MS) that indicates potential relapse and disability, focusing on SWAP-70 antibodies in patients with relapsing-remitting MS (RRMS).
- - Researchers tested serum samples from 26 RRMS patients, finding high levels of SWAP-70 antibodies during attacks compared to remission, and noted a significant link between these antibody levels and various disability indicators.
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