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Long-term effect and safety of mesenchymal stromal cell therapy for radiation-induced hyposalivation in head and neck cancer survivors: A randomised, phase-2, trial.
Clin Cancer Res
January 2025
Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Background: The long-term effect of adipose-derived mesenchymal stromal cells (ASCs) to restore radiation-induced salivary gland hypofunction in previous head and neck cancer patients have not been validated in larger settings.
Methods: The study was the 12-months follow-up of a randomised trial, including patients with hyposalivation. Patients were randomised to receive allogeneic ASCs or placebo in the submandibular glands.
Intraglandular botulinum toxin in postoperative head and neck fistula: a retrospective analysis.
Eur Arch Otorhinolaryngol
December 2024
Department of Otorhinolaryngology and Head- Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.
Purpose: Orocervical (OCF) or pharyngocutaneous fistula (PCF) are one of the disastrous complications of head and neck cancer surgery. Conventional standards of management are predominantly conservative. Though a majority of such patients respond to conservative management, it nevertheless causes significant delay in wound healing.
View Article and Find Full Text PDFEfficacy of Submandibular Gland Excision Versus Preservation During Supraomohyoid Neck Dissection for T1, T2, and N0 Oral Squamous Cell Carcinoma.
Cureus
November 2024
General Surgery and Pediatric Surgery, Kalinga Institute of Medical Sciences, Kalinga Institute of Industrial Technology (Deemed to be University), Bhubaneswar, IND.
Introduction: The present study aims to observe the efficacy of submandibular gland excision vs. preservation during supraomohyoid neck dissection (SOHND) based on the postoperative outcomes for early oral squamous cell carcinoma (OSCC) with clinically N0 neck and xerostomia.
Materials And Methods: A pilot study was conducted to observe the efficacy of preservation vs.
Intraoral microscopic-assisted sialolithotomy for management of medium-large submandibular sialolithiasis: A refined technique.
World J Otorhinolaryngol Head Neck Surg
December 2024
Department of Otorhinolaryngology-Head and Neck Surgery, Suez University, Suez Royal Private Hospital Alexandria Egypt.
Objectives: Sialendoscopy has become the standard treatment for sialolithiasis; however, larger submandibular calculi may require an incisional technique. This study describes and evaluates an intraoral microscopic-assisted sialolithotomy (IMAS) as a refined submandibular stone extraction technique.
Methods: Retrospective case series of 64 submandibular IMAS procedures operated at a tertiary university center and private hospital from 2015 to 2021 were evaluated.
Breast carcinoma metastasis to the submandibular gland: Clinical, sonographic and pathological findings of a rare entity.
Ultrasound
May 2024
Department of Radiology, Eastbourne District General Hospital, Eastbourne, UK.
Article Synopsis
- * Ultrasound is the preferred imaging technique for evaluating submandibular gland issues, revealing features like hypoechoic lesions that may indicate malignancy; smaller low-grade tumors can sometimes appear benign.
- * Early ultrasound-guided core biopsy is crucial for accurate diagnosis when a suspicious lesion is found, facilitating timely management of potential metastatic disease.
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