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Edaravone Improves Motor Dysfunction Following Brachial Plexus Avulsion Injury in Rats.
ACS Chem Neurosci
January 2025
Department of Neurology, Multi-Omics Research Center for Brain Disorders,The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.
Brachial plexus root avulsion (BPRA) is often caused by road collisions, leading to total loss of motor function in the upper limb. At present, effective treatment options remain limited. Edaravone (EDA), a substance that eliminates free radicals, exhibits numerous biological properties, including neuroprotective, antioxidant and anti-inflammatory effects.
View Article and Find Full Text PDFAutogene cevumeran with or without atezolizumab in advanced solid tumors: a phase 1 trial.
Nat Med
January 2025
Department of Medicine-Medical Oncology, University of Colorado Cancer Center, Denver, CO, USA.
Effective targeting of somatic cancer mutations to enhance the efficacy of cancer immunotherapy requires an individualized approach. Autogene cevumeran is a uridine messenger RNA lipoplex-based individualized neoantigen-specific immunotherapy designed from tumor-specific somatic mutation data obtained from tumor tissue of each individual patient to stimulate T cell responses against up to 20 neoantigens. This ongoing phase 1 study evaluated autogene cevumeran as monotherapy (n = 30) and in combination with atezolizumab (n = 183) in pretreated patients with advanced solid tumors.
View Article and Find Full Text PDFIntegrative approaches to m6A and m5C RNA modifications in autism spectrum disorder revealing potential causal variants.
Mamm Genome
December 2024
Department of Biochemistry, Abdul Wali Khan University Mardan, Mardan, 23200, Pakistan.
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that currently affects approximately 1-2% of the global population. Genome-wide studies have identified several loci associated with ASD; however, pinpointing causal variants remains elusive. Therefore, functional studies are essential to discover potential therapeutics for ASD.
View Article and Find Full Text PDFCritical Considerations in Calling Disease-Causing Mutations in Nonsyndromic Oligodontia.
J Clin Med
December 2024
Department of Pediatric Dentistry, School of Dentistry & Dental Research Institute, Seoul National University, Seoul 03080, Republic of Korea.
Oligodontia, the absence of six or more teeth excluding third molars, is a rare genetic condition, unlike hypodontia (missing one or more teeth), which is a relatively common human disease. To identify the genetic etiology of nonsyndromic oligodontia (NSO) families, we performed mutational analysis and investigated the functional effects of identified mutations. Whole-exome sequencing was conducted on recruited families with NSO.
View Article and Find Full Text PDFExploring the genetics, mechanisms, and therapeutic innovations in non-syndromic tooth agenesis.
Morphologie
December 2024
Department of Preventive and Community Dentistry, Faculty of Dentistry, Universidade Federal de Uberlândia, Uberlândia, Brazil. Electronic address:
Article Synopsis
- Tooth agenesis is the congenital absence of one or more teeth due to failures during the normal dental development process, with unclear causes, particularly in non-syndromic cases.
- The study reviewed 53 articles linking specific genes, such as PAX9 and WNT10A, to non-syndromic tooth agenesis, highlighting their roles in tooth formation and signaling pathways.
- Understanding the genetics and molecular mechanisms behind tooth agenesis is crucial for improving diagnosis and developing personalized treatment options, emphasizing the need for ongoing research in this area.
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