Copper-mediated direct aryloxylation of benzamides assisted by an N,O-bidentate directing group.

Org Lett

The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry and ‡School of Chemical Engineering and Energy, Zhengzhou University, Zhengzhou 450001, People's Republic of China.

Published: February 2014

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Article Abstract

Copper-mediated selective mono- or diaryloxylation of benzamides has been achieved by using 2-aminopyridine 1-oxide as a new and removable N,O-bidentate directing group. The reaction system shows a broad substrate scope and provides a straightforward way for the synthesis of mono- and diaryloxylated benzoic acids.

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Source
http://dx.doi.org/10.1021/ol500166dDOI Listing

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