Aim: To analyze the possible interpretations of hyponatremia detected at autopsy in vitreous humor in relation to the cause of death and/or associated pathology (cause of death or a simple marker of the severity of associated diseases).
Material And Methods: Hyponatremia is the most common electrolytic disorder in hospital practice, considered as a risk factor for hospital mortality. We conducted a 3-year forensic casework analysis in view ofestablishing the relationship of hyponatremia with mortality: hyponatremia as a direct cause of death or hyponatremia caused by the severity of the underlying disease which is the cause of death.
Results: The forensic cases are not fully reliable. Although the target question has not been answered, our findings plead for the association of hyponatremia with severe diseases (sick cell syndrome) and not for hyponatremia as a cause of death, but this does not seems to be proven either, the percentage of cases with significant hyponatremia increasing from zero in cases of trauma and sudden violent death to 50% in cases of severe chronic diseases.
Conclusions: The values obtained by us are in agreement with the data in the literature. Our findings plead for the scenario hyponatremia as a marker of the severity of the underlying disease.
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Orphanet J Rare Dis
January 2025
Department of Cardiology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
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Sci Rep
January 2025
Department of Applied Plant Biology, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Debrecen, Hungary.
Sweet corn is highly susceptible to water deprivation, making it crucial to identify effective strategies for enhancing its tolerance to water deficit conditions. This study investigates the novel application of Spermine as a bio-stimulant to improve sweet corn (Zea mays L. var.
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January 2025
Departments of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
Approaches to mitigate the severity of infections and of immune responses are still needed for the treatment of cystic fibrosis (CF) even with the success of highly effective modulator therapies. Previous studies identified reduced levels of melatonin in a CF mouse model related to circadian rhythm dysregulation. Melatonin is known to have immunomodulatory properties and it was hypothesized that treatment with melatonin would improve responses to bacterial infection in CF mice.
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College of Life Sciences, Institute of Life Science and Green Development, Hebei University, Baoding 071002, China; The Key Laboratory of Zoological Systematics and Application, College of Life Sciences, Hebei University, Baoding 071002, China. Electronic address:
Excessive alcohol consumption is a major cause of alcoholic cardiomyopathy (ACM) and myocardial injury. This study aims to investigate the role of transcription factor EB (TFEB) in ethanol-induced cardiac anomalies using a murine model, AC16 human cardiomyocytes, and human plasma. Wild-type mice treated with a TFEB activator (Compound 1) or vehicle (25 mg/kg/d) were challenged with or without ethanol (3 g/kg/d, i.
View Article and Find Full Text PDFThromb Haemost
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Department of Medicine, Jagiellonian University School of Medicine, Cracow, Poland.
Background: Asthma is associated with a prothrombotic state. Plasma factor VIIa-antithrombin complex concentrations (FVIIa-AT) indirectly reflect the interaction of tissue factor (TF) with FVII. Since TF is a key initiator of coagulation in vivo, we hypothesized that FVIIa-AT are higher in asthma.
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