Impact of rofecoxib on progressing of pancreatic fibrous changes in the rats in experimental chronic pancreatitis, caused by L-arginine, was studied up. In 60 male rats chronic pancreatitis was simulated, using intraabdominal L-arginine introduction (100 mg/100 g) through 21 days. Rofecoxib (5 mg/kg) was injected during 14 days to rats of the main group after L-arginine injections were completed. In 35 days of experiment the animals state, the pancreatic amylase and lipase activity in the blood serum, as well as morphological changes in pancreatic gland, were analyzed. Application of rofecoxib have had promoted the postponed pancreatic fibrosis formation, the morphofunctional state of pancreatic gland improvement. The data obtained constitute the experimental substantiation of possibility to apply nonsteroid antiinflammatory medicines in complex of clinical treatment of chronic pancreatitis.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Clinical Variability of Pain Localization in Chronic Pancreatitis.
Pancreas
January 2025
Centre for Pancreatic Diseases & Mech-Sense, Department of Gastroenterology, Aalborg University Hospital, Aalborg, Denmark.
A Modified Procedure to Improve Pancreatic Drainage in Chronic Pancreatitis with Pancreatic Head Dominant Disease.
Pancreas
January 2025
Department of Surgery, University of Minnesota Medical School, Minneapolis, MN.
Objectives: Chronic pancreatitis is a debilitating and progressive inflammatory disease with an altered quality of life due to severe abdominal pain. Pancreaticoduodenectomy is a surgical option for patients with bulky disease involving the head of the pancreas, especially when this disease has progressed to stricture of the bile duct, duodenum, or both. A long term issue associated with this procedure is stricture of the pancreatic anastomosis.
View Article and Find Full Text PDFEndoscopic ultrasound-guided biopsy of healthy pig pancreas - Towards the histological diagnosis of chronic pancreatitis.
Rev Esp Enferm Dig
September 2024
Gastroenterology, Hospital Clínico Universitario de Santiago.
Background: diagnosis of early chronic pancreatitis (CP) is a challenge due to the lack of accurate methods. The ability of endoscopic ultrasound (EUS) guided biopsy to obtain pancreatic core tissue samples in patients with minimal changes of CP and its potential use for the histological diagnosis of early CP are unknown. The aim of the study was to evaluate the ability of different EUS-guided biopsy core needles to obtain histological samples of healthy pig pancreas.
View Article and Find Full Text PDFDuct-related complications of pediatric post-traumatic pancreatitis: A case report from Syria.
Int J Surg Case Rep
January 2025
Gastroenterology Interventional Endoscopy Department, Syrian Specialty Hospital, Damascus, Syria.
Introduction: Pancreatic trauma is a rare type of abdominal injury, representing only 0.3 % of pediatric trauma cases. This condition may progress to chronic pancreatitis and result in multiple complications following damage to the pancreatic duct.
View Article and Find Full Text PDFPancreaticopleural Fistula with Bilateral Pleural Effusion due to Chronic Calcific Pancreatitis.
Indian J Pediatr
January 2025
Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, 342005, India.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!