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Spatial prediction of immunity gaps during a pandemic to inform decision making: A geostatistical case study of COVID-19 in Dominican Republic.
Trop Med Int Health
March 2025
UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia.
Background: To demonstrate the application and utility of geostatistical modelling to provide comprehensive high-resolution understanding of the population's protective immunity during a pandemic and identify pockets with sub-optimal protection.
Methods: Using data from a national cross-sectional household survey of 6620 individuals in the Dominican Republic (DR) from June to October 2021, we developed and applied geostatistical regression models to estimate and predict Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) spike (anti-S) antibodies (Ab) seroprevalence at high resolution (1 km) across heterogeneous areas.
Results: Spatial patterns in population immunity to SARS-CoV-2 varied across the DR.
Evaluating the Efficacy of Premedication in Preventing Hypersensitivity Reactions to Nonionic Contrast Agents.
Biol Pharm Bull
March 2025
Division of Drug Informatics, Keio University Faculty of Pharmacy, Minato-ku, Tokyo 105-8512, Japan.
Iodine-based contrast agents can induce various acute hypersensitivity reactions ranging from mild itching or vomiting shortly after administration to severe hypotension or loss of consciousness. In Japan, steroid premedication is commonly used to prevent acute hypersensitivity reactions. However, little clear evidence supporting its efficacy is available.
View Article and Find Full Text PDFEarly Mobilization of Patients in the Intensive Care Unit: A Quality Improvement Evidence-Based Project.
J Dr Nurs Pract
March 2025
Department of Nursing, Aspen University, Denver, CO, USA
At an urban public acute care hospital, a gap existed in the safety and efficacy of early mobilization (EM) of intensive care unit (ICU) patients, with the need for an evidence-based intervention. A literature review revealed that a nurse-driven mobility protocol could safely achieve early mobility in ICU patients. This quality improvement project aims to utilize a nurse-driven mobility protocol to determine its effects on EM of ICU patients.
View Article and Find Full Text PDFCloning, Expression, Characterization and in silico studies of L-asparaginase from Vibrio sp. (GBPx3).
Biochimie
March 2025
Department of Medical Biotechnology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran; Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran. Electronic address:
L-asparaginase is a critical therapeutic enzyme for treating acute lymphoblastic leukemia (ALL), a common childhood malignancy. In this study, the L-asparaginase coding sequence from halophilic Vibrio sp. (GBPx3) was cloned, expressed in Escherichia coli, and characterized.
View Article and Find Full Text PDFShuxuetong Injection inhibits pyroptosis in acute ischemic stroke via CD44/NLRP3/GSDMD signal.
J Ethnopharmacol
March 2025
Beijing University of Chinese Medicine, Beijing, China 102488. Electronic address:
Ethnopharmacological Relevance: Acute ischemic stroke (AIS) is an important cause of death and disability in the world. Based on the blood stasis syndrome of stroke, Shuxuetong Injection (SXT) is a representative prescription for the treatment of AIS, which extracted by modern technology from Whitmania pigra Whitman (Shuizhi) and Pheretima aspergillum E.Perrier (Dilong).
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