This article is a detailed analysis of the studies of Russian and foreign authors on the epidemiology, clinical features, pathogenesis, risk factors of stress-induced disease of the mucosa of the upper gastrointestinal tract. Also in the article the approaches to drug prevention of this complication are considered. Currently, there are several groups of drugs are suitable for use for this purpose. However, the choice of a specific drug is difficult because of insufficient knowledge of the matter. Data on the incidence and natural history of erosive and ulcerative complications in patients urological profile is limited and very controversial.

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