A 20-year-old woman was found to have a tumor shadow on chest X-ray examination during mass screening and was admitted to our hospital. The chest radiograph revealed a round tumor in the right upper lung field. Chest computed tomography (CT) showed a well-defined, 3-cm-diameter mass in the right upper lobe. The patient underwent a right upper lobectomy under video-assisted thoracoscopic surgery. The postoperative pathological diagnosis was well-differentiated fetal adenocarcinoma (WDFA), stage IA (pT1bN0M0). The patient was well and free of disease four years after surgery. WDFA is a rare pulmonary neoplasm resembling fetal lung and classified as a variant of adenocarcinoma. WDFA occurs in younger people more often than the other histological types of primary lung cancer. An additional young case of WDFA is reported, along with a review of the relevant literature.
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http://dx.doi.org/10.5387/fms.59.89 | DOI Listing |
Am J Surg Pathol
February 2024
Department of Human Genetics.
Germline and somatic pathogenic variants (PVs) in DICER1 , encoding a miRNA biogenesis protein, are associated with a wide variety of highly specific pathologic entities. The lung tumors pleuropulmonary blastoma, pulmonary blastoma (PB), and well-differentiated fetal lung adenocarcinoma (WDFLAC) are all known to harbor DICER1 biallelic variants (loss of function and/or somatic hotspot missense mutations), and all share pathologic features reminiscent of the immature lung. However, the role of DICER1 PVs in non-small cell lung cancer (NSCLC) is relatively unknown.
View Article and Find Full Text PDFJ Surg Case Rep
May 2023
Department of Surgery and Surgical Oncology, HCA East Florida, Fort Lauderdale, Florida, USA.
Hibernomas are rare and benign lipomatous tumors which consist of lobules of cells derived from brown fat. Less than 200 overall cases are reported in the literature which necessitates the need to report more cases for better understanding of this neoplasm. Hibernomas are slowly progressing, painless tumors most frequently located in the subcutaneous thigh, upper trunk, and neck.
View Article and Find Full Text PDFCancer Treat Res Commun
December 2022
Department of Pathology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.
Background: Endometrial cancer in young women (less than 40-year-old) is associated with anovulatory menses, polycystic ovarian syndrome (PCOS) and subfertility. Endometrial cancer occurring in a miscarriage is rare. We highlight a case of endometrial cancer occurring during miscarriage of a non-viable pregnancy, its management and the outcome.
View Article and Find Full Text PDFJ Pediatr Surg
October 2022
Department of Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee, 38105; Division of Pediatric Surgery, Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee, 38105. Electronic address:
J Pediatr Surg
October 2022
Nemours Children's Hospital, 1600 Rockland Road, Wilmington DE 19803, United States. Electronic address:
Background: Hepatoblastoma (HB) requires surgical resection for cure, but only 20-30% of patients have resectable disease at diagnosis. Patients who undergo partial hepatectomy at diagnosis have historically received 4-6 cycles of adjuvant chemotherapy; however, those with 100% well-differentiated fetal histology (WDF) have been observed to have excellent outcomes when treated with surgery alone.
Patients And Methods: Patients on the Children's Oncology Group non randomized, multicenter phase III study, AHEP0731, were stratified based on Evan's stage, tumor histology, and serum alpha-fetoprotein level at diagnosis.
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