Eight new limonoids (1-8) and one new phenol glycoside (9), along with six known compounds, were isolated from the leaves of Azaridachta indica. The structures of 1-9 were elucidated on the basis of spectroscopic data analysis. Compounds isolated were assayed for their cytotoxicity against different cancer cell lines. Moreover, their ability to interact with the molecular chaperone Hsp90, affecting its biological activity, was tested.
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Bioactive limonoids from the leaves of Azaridachta indica (Neem).
J Nat Prod
March 2014
Laboratorio de Medicamentos Organicos Sector Campo de Oro, Departamento de Farmacognosia y Medicamentos Organicos, Universidad de Los Andes , detras del HULA, Mérida, 5101, Venezuela.
Eight new limonoids (1-8) and one new phenol glycoside (9), along with six known compounds, were isolated from the leaves of Azaridachta indica. The structures of 1-9 were elucidated on the basis of spectroscopic data analysis. Compounds isolated were assayed for their cytotoxicity against different cancer cell lines.
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