Due to strict regulatory requirements for pesticide residue analysis, only the results of residue analysis with acceptable quality should be reported. As a consequence proper validation of the measurement method is required. In this context, accuracy, precision, specificity, limit of determination (LOQ), matrix effect, linearity, uncertainty calculation and ruggedness become increasingly important. This paper reports a description of the validation parameters of a fast method for the determination of five phenoxy acid herbicides (2,4-D, MCPA, MCPP, haloxyfop and fluazifop) in food crops. The recoveries were performed in the concentration range from 0.05 to 0.5 mg kg⁻¹ for apples, pears, carrots and celeriac with five replicates at each level. The mean recoveries ranged from 70% to 95% for all crops. The precision of the method expressed as a relative standard deviation (RSD%) was found to be in the range 3-14%. For all herbicides, the linearity response of the detector was tested by correlation coefficients (r² > 0.99) in the concentration range from 0.05 to 0.5 mg kg⁻¹. The LOQ was determined as the lowest spiked level meeting the requirement of accuracy (70-120%) and precision (RSD% < 20% according to European Union guidelines. The uncertainty and robustness were calculated. On the basis of the results, the method can be considered fast, simple and robust and is suitable to be applied to the analysis of studied herbicides in routine testing laboratories.
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http://dx.doi.org/10.1080/19440049.2014.891296 | DOI Listing |
J Med Internet Res
January 2025
Division of Clinical Pathology, Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Background: Sepsis, a critical global health challenge, accounted for approximately 20% of worldwide deaths in 2017. Although the Sequential Organ Failure Assessment (SOFA) score standardizes the diagnosis of organ dysfunction, early sepsis detection remains challenging due to its insidious symptoms. Current diagnostic methods, including clinical assessments and laboratory tests, frequently lack the speed and specificity needed for timely intervention, particularly in vulnerable populations such as older adults, intensive care unit (ICU) patients, and those with compromised immune systems.
View Article and Find Full Text PDFPLoS One
January 2025
NIE-Indian Council of Medical Research-National Institute of Epidemiology, Chennai, India.
Background: Judicious utilisation of tertiary care facilities through appropriate risk stratification assumes priority, in a raging pandemic, of the nature of delta variant-predominated second wave of COVID-19 pandemic in India. Prioritisation of tertiary care, through a scientifically validated risk score, would maximise recovery without compromising individual safety, but importantly without straining the health system.
Methods: De-identified data of COVID-19 confirmed patients admitted to a tertiary care hospital in South India, between April 1, 2021 and July 31, 2021, corresponding to the peak of COVID-19 second wave, were analysed after segregating into 'survivors' or 'non-survivors' to evaluate the risk factors for COVID-19 mortality at admission and formulate a risk score with easily obtainable but clinically relevant parameters for accurate patient triaging.
PLoS One
January 2025
Department of Preventive and Social Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
This study examined the ability of the following five dynamic models for predicting pulmonary tuberculosis (PTB) incidence in a prison setting: the Wells-Riley equation, two Rudnick & Milton-proposed models based on air changes per hour and liters per second per person, the Issarow et al. model, and the applied susceptible-exposed-infected-recovered (SEIR) tuberculosis (TB) transmission model. This 1-year prospective cohort study employed 985 cells from three Thai prisons (one prison with 652 cells as the in-sample, and two prisons with 333 cells as the out-of-sample).
View Article and Find Full Text PDFInt J Numer Method Biomed Eng
January 2025
Hebei Provincial Key Laboratory of Portal Hypertension and Cirrhosis, Xingtai People's Hospital, Xingtai, China; Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.
Transjugular intrahepatic portosystemic shunt (TIPS) is a widely used surgery for portal hypertension. In clinical practice, the diameter of the stent forming a shunt is usually selected empirically, which will influence the postoperative portal pressure. Clinical studies found that inappropriate portal pressure after TIPS is responsible for poor prognosis; however, there is no scheme to predict postoperative portal pressure.
View Article and Find Full Text PDFProstate
January 2025
Department of Urology, Weill Cornell Medicine, New York City, New York, USA.
Purpose: Actinium-225 labeled prostate-specific membrane antigen (PSMA) targeted radionuclide therapy has emerged as a potential treatment option in the management of men with metastatic castrate-resistant prostate cancer (mCRPC). This study investigated molecular imaging-derived parameters and compared imaging response of lesions categorized by tumor site.
Methods: Men with mCRPC treated with [225Ac]Ac-J591 from 2017 to 2022 at our center on two prospective trials (NCT03276572 and NCT04506567) with pre- and post-treatment [68Ga]Ga-PSMA-11 Positron Emission Tomography (PET) imaging studies available were included.
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