AI Article Synopsis
- Researchers isolated two new compounds, scutebatas S and T, along with a previously known compound, scutebata D, from the plant Scutellaria barbata using various chromatographic methods.
- The structures of these compounds were determined using advanced techniques like high-resolution electrospray ionization mass spectrometry and NMR spectroscopy.
- Compounds 1 (scutebatas S) and 3 (scutebata D) showed moderate cytotoxic effects on certain human cancer cells, while compound 2 (scutebatas T) did not exhibit any activity against the tested cancer cell lines.
Article Abstract
Various chromatographic separations of the aerial parts of Scutellaria barbata afforded two new neoclerodane diterpenoids, scutebatas S and T (1 and 2), along with scutebata D (3). Their structures were elucidated by spectroscopic methods including high-resolution electrospray ionization mass spectrometry, 1D and 2D NMR and comparison with the literature values. Compounds 1 and 3 exhibited moderate cytotoxic activities against HL-60 (promyeloblast) human cancer cells. Weak cytotoxic effects toward four tested human cancer cell lines including KB (epidermoid carcinoma), LU-1 (lung adenocarcinoma), MCF7 (breast cancer), and Hep-G2 (hepatoma cancer) were observed for 1 and 3; whereas 2 was inactive on all five tested cell lines.
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| http://dx.doi.org/10.1080/10286020.2014.882912 | DOI Listing |
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