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Methods for measuring antibody-dependent cell-mediated cytotoxicity in vitro. | LitMetric

Methods for measuring antibody-dependent cell-mediated cytotoxicity in vitro.

Methods Mol Biol

Analytical Development and Quality Control, Genentech Inc., South San Francisco, CA, USA.

Published: September 2014

Antibody-dependent cell-mediated cytotoxicity (ADCC) is a relevant characteristic to measure for a number of therapeutic monoclonal antibodies (mAbs) under development. ADCC is a mechanism by which antibody-opsonized, infected, or cancerous cells are destroyed by FcγRIII (CD16)-expressing effector cells. Here we describe three methods that can be used to quantify the ADCC activity of mAbs by measuring distinct aspects of the ADCC mechanism.

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Source
http://dx.doi.org/10.1007/978-1-4939-0326-9_5DOI Listing

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