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Pax genes: regulators of lineage specification and progenitor cell maintenance. | LitMetric

Pax genes: regulators of lineage specification and progenitor cell maintenance.

Development

School of Medical Sciences, Edith Cowan University, Joondalup, WA 6027, Australia.

Published: February 2014

AI Article Synopsis

  • * Abnormalities from mutant Pax gene expression can lead to significant developmental issues, showcasing their importance in lineage determination.
  • * The review explores Pax gene functions in development, tissue regeneration, and their implications in adult diseases, including the role in cancer.

Article Abstract

Pax genes encode a family of transcription factors that orchestrate complex processes of lineage determination in the developing embryo. Their key role is to specify and maintain progenitor cells through use of complex molecular mechanisms such as alternate RNA splice forms and gene activation or inhibition in conjunction with protein co-factors. The significance of Pax genes in development is highlighted by abnormalities that arise from the expression of mutant Pax genes. Here, we review the molecular functions of Pax genes during development and detail the regulatory mechanisms by which they specify and maintain progenitor cells across various tissue lineages. We also discuss mechanistic insights into the roles of Pax genes in regeneration and in adult diseases, including cancer.

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.091785DOI Listing

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