Hematopoietic stem cells (HSC) provide for contmuous replenishment of the entire immune and hematopoietic systems, and also replenish themselves in a process termed self-renewal (1).The HSCs can be enriched from hematopoietic tissues using MAbs that bind to the CD34 antigen, a universally recognized marker for hematopoietic progenitors (2-4).Enriched HSC populations are being widely investigated for use in transplantation and gene therapy because they appear to provide rapid hematopoietic reconstitution in myeloablated patients (5-11), and they offer good targets for gene transfer (12-17).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1385/0-89603-484-4:249 | DOI Listing |
Publication Analysis
Top Keywords
gene transfer
8
hematopoietic
5
methods retrovirus-mediated
4
retrovirus-mediated gene
4
transfer cd34+
4
cd34+ enriched
4
enriched cells
4
cells hematopoietic
4
hematopoietic stem
4
stem cells
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!