Purpose: To investigate the effect of topical glucose on visual parameters in individuals with primary open-angle glaucoma (POAG).
Design: Double-blind, randomized, crossover study.
Participants: Nondiabetic pseudophakic patients with definite POAG were recruited; 29 eyes of 16 individuals participated in study 1. A follow-up study (study 2) included 14 eyes of 7 individuals.
Intervention: Eyes were randomly allocated to receive 50% glucose or saline eye drops every 5 minutes for 60 minutes.
Main Outcome Measures: The contrast sensitivity and best-corrected logarithm of the minimum angle of resolution (logMAR).
Results: The 50% glucose reached the vitreous in pseudophakic but not phakic individuals. Glucose significantly improved the mean contrast sensitivity at 12 cycles/degree compared with 0.9% saline by 0.26 log units (95% confidence interval [CI], 0.13-0.38; P < 0.001) and 0.40 log units (95% CI, 0.17-0.60; P < 0.001) in the follow-up study. The intraocular pressure, refraction, and central corneal thickness were not affected by glucose; age was not a significant predictor of the response.
Conclusions: Topical glucose temporarily improves psychophysical visual parameters in some individuals with POAG, suggesting that neuronal energy substrate delivery to the vitreous reservoir may recover function of "sick" retinal neurons.
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