N-Heterocyclic carbenes catalyzed hydrophosphonylation reaction of α-ketoesters and α-trifluoromethyl ketones was developed. Under the catalysis of 10 mol% IPr, α-ketoesters or α-trifluoromethyl ketones reacted with dialkyl phosphites to provide quaternary α-hydroxyphosphonates in good to excellent yield.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893873 | PMC |
| http://dx.doi.org/10.1155/2013/890187 | DOI Listing |
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