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The use of automated insulin delivery around physical activity and exercise in type 1 diabetes: a position statement of the European Association for the Study of Diabetes (EASD) and the International Society for Pediatric and Adolescent Diabetes (ISPAD).
Diabetologia
February 2025
School of Kinesiology and Health Science, York University, Toronto, ON, Canada.
Regular physical activity and exercise (PA) are cornerstones of diabetes care for individuals with type 1 diabetes. In recent years, the availability of automated insulin delivery (AID) systems has improved the ability of people with type 1 diabetes to achieve the recommended glucose target ranges. PA provide additional health benefits but can cause glucose fluctuations, which challenges current AID systems.
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- - The study explores the long-term effects of SARS-CoV-2 in children and young people (CYP), identifying a condition called post-COVID-19 condition (PCC) and examining symptoms and impacts up to 24 months post-infection.
- - Out of 31,012 eligible CYP, 12,632 participated, revealing that 7.2% consistently met the PCC criteria over two years, with around 20-25% reporting three or more symptoms, and symptom severity was found to be higher in older and more deprived groups.
- - The findings emphasize the necessity of longitudinal research to better understand both the prevalence and severity of PCC symptoms in CYP, as well as the importance of monitoring clinical impairment over
Peripheral neuropathy (PN) is a significant cause of morbidity associated with Waldenström macroglobulinemia (WM). The phase 3 ASPEN study compared the efficacy and safety of zanubrutinib with ibrutinib in patients with WM. This ad hoc analysis examined treatment outcomes with zanubrutinib or ibrutinib on PN symptoms associated with WM in patients enrolled in ASPEN.
View Article and Find Full Text PDFLife-threatening antibodies: The discovery of anaphylaxis.
Immunol Rev
November 2024
UMR 7219 SPHERE, CNRS/Université Paris-Cité, Paris, France.
It was at the turn of the 20th century, that immune serum was found both to save children dying from toxins of deadly pathogens, and to kill a dog within minutes following an injection of harmless doses of sea anemone toxins. This means that, before being formally identified in immune serum, antibodies were already known to be both protective and pathogenic. For this provocative finding, Charles Richet was awarded the 1913 Nobel Prize in Physiology or Medicine.
View Article and Find Full Text PDFRisk of celiac disease autoimmunity is modified by interactions between CD247 and environmental exposures.
Sci Rep
October 2024
Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Season of birth, viral infections, HLA haplogenotypes and non-HLA variants are implicated in the development of celiac disease and celiac disease autoimmunity, suggesting a combined role of genes and environmental exposures. The aim of the study was to further decipher the biological pathways conveying the season of birth effect in celiac disease autoimmunity to gain novel insights into the early pathogenesis of celiac disease. Interactions between season of birth, genetics, and early-life environmental factors on the risk of celiac autoimmunity were investigated in the multicenter TEDDY birth cohort study.
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