AI Article Synopsis
- Nar1p is an essential protein in yeast that is similar to bacterial hydrogenases and is crucial for the maturation of certain iron-sulfur proteins.
- Nar1p helps regulate oxygen sensitivity in yeast and C. elegans and its deficiency leads to shorter lifespans and increased sensitivity to oxidative stress from paraquat.
- Enhancing mitochondrial superoxide dismutase levels can rescue the negative effects of Nar1 deficiency, indicating that Nar1p plays a protective role against oxidative stress and contributes to lifespan extension.
Article Abstract
Saccharomyces cerevisiae Nar1p is an essential Fe/S protein that exhibits striking similarity to bacterial iron-only hydrogenases. Nar1p is required for the maturation of cytosolic and nuclear, but not of mitochondrial Fe/S proteins, and plays a role in modulating sensitivity to oxygen in both yeast and Caenorhabditis elegans through unknown mechanisms. Here we report that Nar1 deficiency results in shortened lifespan and sensitivity to paraquat that is rescued by increased expression of mitochondrial superoxide dismutase. These data suggest that Nar1p promotes protection against oxidative stress and define a new role for Nar1p in promoting replicative lifespan.
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Article Synopsis
- Nar1p is an essential protein in yeast that is similar to bacterial hydrogenases and is crucial for the maturation of certain iron-sulfur proteins.
- Nar1p helps regulate oxygen sensitivity in yeast and C. elegans and its deficiency leads to shorter lifespans and increased sensitivity to oxidative stress from paraquat.
- Enhancing mitochondrial superoxide dismutase levels can rescue the negative effects of Nar1 deficiency, indicating that Nar1p plays a protective role against oxidative stress and contributes to lifespan extension.
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