Escape of DNA from a weakly biased thin nanopore: experimental evidence for a universal diffusive behavior.

Phys Rev Lett

Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA and School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.

Published: December 2013

We report experimental escape time distributions of double-stranded DNA molecules initially threaded halfway through a thin solid-state nanopore. We find a universal behavior of the escape time distributions consistent with a one-dimensional first passage formulation notwithstanding the geometry of the experiment and the potential role of complex molecule-liquid-pore interactions. Diffusion constants that depend on the molecule length and pore size are determined. Also discussed are the practical implications of long time diffusive molecule trapping in the nanopore.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085674PMC
http://dx.doi.org/10.1103/PhysRevLett.111.248301DOI Listing

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