We study the statistics of near-extreme events of Brownian motion (BM) on the time interval [0,t]. We focus on the density of states near the maximum, ρ(r,t), which is the amount of time spent by the process at a distance r from the maximum. We develop a path integral approach to study functionals of the maximum of BM, which allows us to study the full probability density function of ρ(r,t) and obtain an explicit expression for the moments <[ρ(r,t)]k> for arbitrary integer k. We also study near extremes of constrained BM, like the Brownian bridge. Finally we also present numerical simulations to check our analytical results.
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http://dx.doi.org/10.1103/PhysRevLett.111.240601 | DOI Listing |
Biostatistics
December 2024
Department of Statistics, University of Connecticut, 215 Glenbrook Road Unit 4120, Storrs, CT 06269, United States.
Patients with type 2 diabetes need to closely monitor blood sugar levels as their routine diabetes self-management. Although many treatment agents aim to tightly control blood sugar, hypoglycemia often stands as an adverse event. In practice, patients can observe hypoglycemic events more easily than hyperglycemic events due to the perception of neurogenic symptoms.
View Article and Find Full Text PDFEvolution
January 2025
Department of Geosciences, Pennsylvania State University, State College, PA, USA.
Seed size is a trait which determines survival rates for individual plants and can vary as a result of numerous trade-offs. In the palm family (Arecaceae) today, there is great variation in seed sizes. Past studies attempting to establish drivers for palm seed evolution have sometimes yielded contradictory findings in part because modern seed size variations are complicated by long-term legacies, including biogeographic differences across lineages.
View Article and Find Full Text PDFJ Chem Phys
January 2025
Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan.
Two-dimensional (2D) vibrational spectroscopy is a powerful means of investigating the structure and dynamics of complex molecules in condensed phases. However, even in theory, analysis of 2D spectra resulting from complex inter- and intra-molecular motions using only molecular dynamics methods is not easy. This is because molecular motions comprise complex multiple modes and peaks broaden and overlap owing to various relaxation processes and inhomogeneous broadening.
View Article and Find Full Text PDFLangmuir
January 2025
Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Straße 6, 01069 Dresden, Germany.
Near-infrared (NIR) controlled drug delivery systems have drawn a lot of attention throughout the past few decades due to the deep penetration depth and comparatively minor side effects of the stimulus. In this study, we introduce an innovative approach for gastric cancer treatment by combining photothermal infrared-sensitive gold nanorods (AuNRs) with a conjugated microporous polymer (CMP) to create a drug delivery system tailored for transporting the cytostatic drug 5-fluorouracil (5-FU). CMPs are fully conjugated networks with high internal surface areas that can be precisely tailored to the adsorption and transport of active compounds through the right choice of chemical functionalities.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Mathematics, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia.
This work considers a stochastic form of an extended version of the Kairat-II equation by adding Browning motion into the deterministic equation. Two analytical approaches are utilized to derive analytical solutions of the modified equation. The first method is the modified Tanh technique linked with the Riccati equation, which is implemented to extract some closed-form solutions in the form of tangent and cotangent functions.
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