AI Article Synopsis
- YAP and TAZ proteins are essential for adult cardiac progenitor cells to sense their environment and decide their fate based on ECM composition and mechanical signals.
- Their localization within the cell changes in response to variations in substrate strength and structure, influencing heart cell behavior.
- Targeting YAP/TAZ could be a strategy to guide cardiac progenitor cell development, helping maintain heart health, especially after injury.
Article Abstract
Stem cell responsiveness to extracellular matrix (ECM) composition and mechanical cues has been the subject of a number of investigations so far, yet the molecular mechanisms underlying stem cell mechano-biology still need full clarification. Here we demonstrate that the paralog proteins YAP and TAZ exert a crucial role in adult cardiac progenitor cell mechano-sensing and fate decision. Cardiac progenitors respond to dynamic modifications in substrate rigidity and nanopattern by promptly changing YAP/TAZ intracellular localization. We identify a novel activity of YAP and TAZ in the regulation of tubulogenesis in 3D environments and highlight a role for YAP/TAZ in cardiac progenitor proliferation and differentiation. Furthermore, we show that YAP/TAZ expression is triggered in the heart cells located at the infarct border zone. Our results suggest a fundamental role for the YAP/TAZ axis in the response of resident progenitor cells to the modifications in microenvironment nanostructure and mechanics, thereby contributing to the maintenance of myocardial homeostasis in the adult heart. These proteins are indicated as potential targets to control cardiac progenitor cell fate by materials design.
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| http://dx.doi.org/10.1021/nn4058984 | DOI Listing |
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