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Role of hypoxia inducible factor HIF-1 in heart valves.
Glob Cardiol Sci Pract
May 2023
Magdi Yacoub Institute, Heart Science Centre, Harefield, Middlesex, U.K.
The 2016 Albert Lasker Basic Medical Research Award and subsequently the 2019 Nobel Prize in Physiology or Medicine were awarded to William Kaelin, Jr., Sir Peter Ratcliffe, and Gregg Semenza for their work on how cells sense and adapt to hypoxic conditions. Their work showed that the changes in gene expression, cell metabolism, and tissue remodelling that occur in response to low oxygen concentrations are orchestrated by the transcription factor, hypoxia inducible factor-1 (HIF-1).
View Article and Find Full Text PDFSir Magdi H. Yacoub, the Leonardo da Vinci of cardiac surgery.
Proc (Bayl Univ Med Cent)
January 2019
The second half of the 20th century witnessed the emergence and the triumph of cardiac surgery. One of the legends of the period is Sir Magdi H. Yacoub (1935-), pioneer surgeon, scientist, master craftsman, and philanthropist.
View Article and Find Full Text PDFProfessor Sir Magdi Yacoub and the Aswan Heart Centre.
J Am Coll Cardiol
September 2018
American College of Cardiology, Washington, DC. Electronic address:
A Bentall Is Not a Bentall Is Not a Bentall: The Evolution of Aortic Root Surgery.
Aorta (Stamford)
October 2014
New York University Langone Medical Center, New York, New York, USA.
Background: Aortic root pathology had been a known entity with a progressive and catastrophic course, long before the methods to surgically address them were first developed. Once reliable cardiopulmonary bypass was established, surgeons were able to pioneer new operative techniques, and in the half-century to follow, countless modifications and refinements have provided today's surgeons with the surgical approaches that are currently at their disposal.
History: Denton Cooley and Michael De Bakey reported the first successful surgical intervention for aneurysms involving the ascending aorta in 1956.
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