While risk factors for konzo are known, determinants of cognitive impairment in konzo-affected children remain unknown. We anchored cognitive performance (KABC-II scores) to serum levels of free-thyroxine (free-T4), thyroid-stimulating hormone (TSH), albumin, and motor proficiency (BOT-2 scores) in 40 children including 21 with konzo (median age: 9 years) and 19 without konzo (median age: 8 years). A multiple regression model was used to determine variables associated with changes in KABC-II scores. Age (β: -0.818, 95% CI: -1.48, -0.152) (p = 0.018), gender (β: -5.72; 95% CI: -9.87, -1.57 for females) (p = 0.009), BOT-2 score (β: 0.390; 95% CI: 0.113, 0.667) (p = 0.008), and free-T4 (β: 1.88; 95% CI: 0.009, 3.74) (p = 0.049) explained 61.1 % of variation in KABC-II scores. Subclinical hypothyroidism was not associated with poor cognition. A crude association was found between serum albumin and KABC-II scores (β: 1.26; 95 % CI: 0.136, 2.39) (p = 0.029). On spot urinary thiocyanate reached 688 μmol/l in children without konzo and 1,032 μmol/L in those with konzo. Female gender and low serum albumin are risk factors common to cognitive and proportionally associated motor deficits in children exposed to cassava cyanogens. The two types of deficits may share common mechanisms.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024334 | PMC |
| http://dx.doi.org/10.1007/s11011-014-9492-9 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Associations between sociodemographic exposures, growth and development during infancy with development at the age of eight years among children: Analysis of a maternal education trial in rural Uganda.
J Glob Health
December 2024
Department of Nutrition, IMB, University of Oslo, Oslo, Norway.
Background: Links between early life exposures and child development later in life are not sufficiently explored in low- and middle-income countries. We studied associations between sociodemographic variables, growth and development at six to eight months with developmental outcomes at eight years.
Methods: We used data from a maternal education trial which included 511 mother-infant pairs at children's age of six to eight months (baseline).
Background: Few trials have explored long-term effects of interventions designed to reduce child stunting. We evaluated school-age outcomes in rural Zimbabwean children who received cluster-randomised water, sanitation and hygiene (WASH) and/or infant and young child feeding (IYCF) interventions from pregnancy up to 18 months of age.
Methods: The Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial enrolled pregnant women from two rural Zimbabwean districts (Chirumanzu and Shurugwi) between 2012 and 2015, and cluster-randomised them using a 2 × 2 factorial design to standard-of-care, WASH, IYCF, or combined WASH & IYCF, with a co-primary outcome of height-for-age Z-score and haemoglobin at 18 months (clinicaltrials.
Correlation of screen exposure to stress, learning, cognitive and language performance in children.
Eur Child Adolesc Psychiatry
October 2024
Chair of Social Pediatrics, TUM School of Medicine, Technical University of Munich, Munich, Germany.
The omnipresence of mobile screens and convenience to operate them has led to increased screen time for young children whereas the sequelae of prolonged exposure are not known yet. 70 refugee children (RG) and 111 children of a clinical comparison group (CG) from a help-seeking population (age: M = 5.10; SD = 1.
View Article and Find Full Text PDFArticle Synopsis
- - Over 16 million children were born HIV-free despite exposure during pregnancy by 2022, but those who are HIV-free exhibit worse health and development outcomes, leading to the need for further research on their long-term effects compared to unexposed children.
- - The SHINE trial in rural Zimbabwe tracked growth and cognitive development in children born HIV-free compared to unexposed children, evaluating participants at age 7 using a variety of assessments that included measurements of height, haemoglobin, cognitive abilities, and physical fitness.
- - The study aimed to understand the differences in health outcomes between the two groups and utilized advanced statistical methods to analyze the collected data, considering various demographic and socioeconomic factors affecting the children's development.
Piloting the adaptation of the Kaufman Assessment Battery for Children-2 edition (KABC-II) to assess school-age neurodevelopment in rural Zimbabwe.
Wellcome Open Res
May 2024
Department of Genomics and Child Health, Queen Mary University of London, London, E1 4AT, UK.
Background: Neurodevelopment assessment tools for low-resource settings are urgently needed. However, most available tools were developed in high-income settings and may lack cross-cultural validity.
Methods: We piloted and adapted two subtests within the planning domain of the Kaufman Assessment Battery for Children-2nd edition (KABC-II) for use in rural Zimbabwean children aged 7years.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!