Combined effects of poststimulation and postextrasystolic potentiation (PESP) were studied in the rat papillary muscles. The constant PESP augmentation of isometric force triggered by extrasystolic stimulus was shown for 2-8 poststimulatory potentiated contractions. The PESP was not dependent upon the Ca2+ concentration within the 0.5-1.2 mM range. The findings corroborate the postulate that the PESP in cardiomyocytes is associated with special Ca2+ store which is triggered by two APs: regular and extrasystolic ones.
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