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A risk prediction model for adult patients with difficult intravenous access.
J Vasc Access
January 2025
Nursing Department, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Background: The challenges posed by difficult intravenous access (DIVA) in clinical treatment are not only related to technical difficulties but also have the potential to affect the quality of patient care and overall experience. It is crucial to adopt effective strategies to address difficult intravenous access. Currently, the assessment of difficult veins largely relies on individual perception and experience, which introduces a significant degree of subjectivity.
View Article and Find Full Text PDFPeripheral nerve regeneration using a bioresorbable silk fibroin-based artificial nerve conduit fabricated via a novel freeze-thaw process.
Sci Rep
January 2025
Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan.
While silk fibroin (SF) obtained from silkworm cocoons is expected to become a next-generation natural polymer, a fabrication method for SF-based artificial nerve conduits (SFCs) has not yet been established. Here, we report a bioresorbable SFC, fabricated using a novel freeze-thaw process, which ensures biosafety by avoiding any harmful chemical additives. The SFC demonstrated favorable biocompatibility (high hydrophilicity and porosity with a water content of > 90%), structural stability (stiffness, toughness, and elasticity), and biodegradability, making it an ideal candidate for nerve regeneration.
View Article and Find Full Text PDFRegulation of circadian gene activity in fibroblasts from ADHD patients through Rosiglitazone: a pilot study.
J Neural Transm (Vienna)
January 2025
Chair of Vascular Neurology, Dementia and Ageing, University Hospital Essen, Essen University Medical School, University of Duisburg-Essen, 45147, Essen, Germany.
Attention-deficit/hyperactivity disorder (ADHD) is a frequently observed condition, with about 70% of individuals diagnosed with ADHD experiencing irregular sleep-wake patterns. Beyond the primary symptoms of ADHD, there is a significant overlap with sleep-related issues, indicating that disrupted sleep patterns may exacerbate ADHD symptoms. ADHD-related sleep problems can be traced to a delayed circadian rhythm and a later onset of melatonin production.
View Article and Find Full Text PDFUpdates in Arterial Ulcers.
Nurs Clin North Am
March 2025
Division of Vascular, Endovascular, and Wound Surgery, Department of Surgery and Medical Education, University of Toledo, Mail Stop 1095, 3000 Arlington Avenue, Toledo, OH 43614-2598, USA. Electronic address:
Arterial ulcers are a clinical symptom of a complex array of underlying comorbid factors, namely peripheral artery disease (PAD). Chronic limb-threatening ischemia is representative of end-stage PAD. Ulcers of other etiologies can carry an arterial component, mandating recognition of risk factors, a comprehensive history and physical examination, and appropriate diagnostic testing in lower extremity ulcers.
View Article and Find Full Text PDFEvaluation of Mesoporous Silica Nanoparticles as Carriers of Triarylmethyl Radical Spin Probes for EPR Oximetry.
J Phys Chem B
January 2025
Department of Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506, United States.
measurement and mapping of oxygen levels within the tissues are crucial in understanding the physiopathological processes of numerous diseases, such as cancer, diabetes, or peripheral vascular diseases. Electron paramagnetic resonance (EPR) associated with biocompatible exogenous spin probes, such as Ox071 triarylmethyl (TAM) radical, is becoming the new gold standard for oxygen mapping in preclinical settings. However, these probes do not show tissue selectivity when injected systemically, and they are not cell permeable, reporting oxygen from the extracellular compartment only.
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