AI Article Synopsis
- The ubiquitin system in eukaryotes involves post-translational modification of proteins through ubiquitylation, which affects protein activity, location, or marks them for degradation.
- This system is essential for various cellular processes and has been found to be particularly important for the survival and spread of human malaria parasites.
- The review focuses on the ubiquitin system in the malaria parasite Plasmodium and its potential role in the development of drug-resistant malaria strains.
Article Abstract
Exploration of the ubiquitin system in eukaryotes has shown that the chemical modification of proteins by ubiquitin, known as ubiquitylation, is an incredibly important post-translational event that is crucial to numerous cellular processes. Ubiquitylation is carried out by a series of enzymes that specifically target proteins to either change their activity or their location or earmark them for degradation. Using a wide range of genome-wide approaches, the ubiquitin system has been shown to be of particular importance in the survival and propagation of the human malaria parasites. In this review, we highlight our current understanding of the ubiquitin system in Plasmodium, and discuss its possible role in the development of drug resistant malaria strains.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990246 | PMC |
| http://dx.doi.org/10.1039/c3mb70506d | DOI Listing |
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